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High mobility group box 1 levels in large vessel vasculitis are not associated with disease activity but are influenced by age and statins

Overview of attention for article published in Arthritis Research & Therapy, June 2015
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Title
High mobility group box 1 levels in large vessel vasculitis are not associated with disease activity but are influenced by age and statins
Published in
Arthritis Research & Therapy, June 2015
DOI 10.1186/s13075-015-0672-8
Pubmed ID
Authors

Alexandre W. S. de Souza, Kornelis S. M. van der Geest, Elisabeth Brouwer, Frederico A. G. Pinheiro, Ana Cecília Diniz Oliveira, Emília Inoue Sato, Luis Eduardo C. Andrade, Marc Bijl, Johanna Westra, Cees G. M. Kallenberg

Abstract

Takayasu arteritis (TA) and giant cell arteritis (GCA) are large vessel vasculitides (LVV) which usually present as granulomatous inflammation in arterial walls. High mobility group box-1 (HMGB1) is a nuclear protein that acts as an alarmin when released by dying or activated cells. This study aims to evaluate whether serum HMGB1 can be used as a biomarker in LVV. Twenty nine consecutive TA patients with 29 healthy controls (HC) were evaluated in a cross-sectional study. Eighteen consecutive GCA patients with 16 HC were evaluated at the onset of disease and in part of them during follow-up. Serum HMGB1 levels were measured by enzyme-linked immunosorbent assay. In GCA patients at disease onset mean serum HMGB1 levels did not differ from HC (5.74 ± 4.19 ng/ml vs. 4.17 ± 3.14 ng/ml; p = 0.230). No differences in HMGB1 levels were found between GCA patients with and without polymyalgia rheumatica (p = 0.167), ischemic manifestations (p = 0.873), systemic manifestations (p = 0.474) or relapsing disease (p = 0.608). During follow-up, no significant fluctuations on serum HMGB1 levels were observed from baseline to 3 months (n = 13) (p = 0.075), 12 months (n = 6) (p = 0.093) and at the first relapse (n = 4) (p = 0.202). Serum HMGB1 levels did not differ between TA patients and HC [1.19 (0.45-2.10)ng/ml vs. 1.46 (0.89-3.34)ng/ml; p = 0.181] and no difference was found between TA patients with active disease and in remission [1.31 (0.63-2.16)ng/ml vs. 0.75 (0.39-2.05)ng/ml; p = 0.281]. HMGB1 levels were significantly lower in 16 TA patients on statins compared with 13 patients without statins [0.59 (0.29-1.46)ng/ml vs. 1.93 (0.88-3.34)ng/ml; p = 0.019]. Age was independently associated with higher HMGB1 levels regardless of LVV or control status. Patients with TA and GCA present similar serum HMGB1 levels compared with HC. Serum HMGB1 is not useful to discriminate between active disease and remission. In TA, use of statins was associated with lower HMGB1 levels. HMGB1 is not a biomarker for LVV.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Unknown 27 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 18%
Other 4 14%
Student > Ph. D. Student 4 14%
Student > Postgraduate 3 11%
Librarian 2 7%
Other 6 21%
Unknown 4 14%
Readers by discipline Count As %
Medicine and Dentistry 13 46%
Biochemistry, Genetics and Molecular Biology 2 7%
Psychology 2 7%
Computer Science 1 4%
Immunology and Microbiology 1 4%
Other 5 18%
Unknown 4 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2016.
All research outputs
#20,656,791
of 25,380,192 outputs
Outputs from Arthritis Research & Therapy
#2,879
of 3,351 outputs
Outputs of similar age
#202,863
of 276,827 outputs
Outputs of similar age from Arthritis Research & Therapy
#52
of 61 outputs
Altmetric has tracked 25,380,192 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,351 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,827 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.