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Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, May 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

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4 tweeters

Citations

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32 Dimensions

Readers on

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107 Mendeley
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Title
Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage
Published in
Memórias do Instituto Oswaldo Cruz, May 2018
DOI 10.1590/0074-02760170542
Pubmed ID
Authors

Felipe Gomes Naveca, Gemilson Soares Pontes, Aileen Yu-hen Chang, George Allan Villarouco da Silva, Valdinete Alves do Nascimento, Dana Cristina da Silva Monteiro, Marineide Souza da Silva, Lígia Fernandes Abdalla, João Hugo Abdalla Santos, Tatiana Amaral Pires de Almeida, Matilde del Carmen Contreras Mejía, Tirza Gabrielle Ramos de Mesquita, Helia Valeria de Souza Encarnação, Matheus de Souza Gomes, Laurence Rodrigues Amaral, Ana Carolina Campi-Azevedo, Jordana Graziela Coelho-dos-Reis, Lis Ribeiro do Vale Antonelli, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Rajendranath Ramasawmy

Abstract

Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis. To define the immunologic biomarkers that correlate with acute ZIKV infection. We characterized the levels of circulating cytokines, chemokines, and growth factors in 54 infected patients of both genders at five different time points after symptom onset using microbeads multiplex immunoassay; comparison to 100 age-matched controls was performed for statistical analysis and data mining. ZIKV-infected patients present a striking systemic inflammatory response with high levels of pro-inflammatory mediators. Despite the strong inflammatory pattern, IL-1Ra and IL-4 are also induced during the acute infection. Interestingly, the inflammatory cytokines IL-1β, IL-13, IL-17, TNF-α, and IFN-γ; chemokines CXCL8, CCL2, CCL5; and the growth factor G-CSF, displayed a bimodal distribution accompanying viremia. While this is the first manuscript to document bimodal distributions of viremia in ZIKV infection, this has been documented in other viral infections, with a primary viremia peak during mild systemic disease and a secondary peak associated with distribution of the virus to organs and tissues. Biomarker network analysis demonstrated distinct dynamics in concurrence with the bimodal viremia profiles at different time points during ZIKV infection. Such a robust cytokine and chemokine response has been associated with blood-brain barrier permeability and neuroinvasiveness in other flaviviral infections. High-dimensional data analysis further identified CXCL10, a chemokine involved in foetal neuron apoptosis and Guillain-Barré syndrome, as the most promising biomarker of acute ZIKV infection for potential clinical application.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 107 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 19 18%
Researcher 16 15%
Student > Master 14 13%
Student > Doctoral Student 12 11%
Student > Ph. D. Student 12 11%
Other 19 18%
Unknown 15 14%
Readers by discipline Count As %
Immunology and Microbiology 26 24%
Biochemistry, Genetics and Molecular Biology 14 13%
Medicine and Dentistry 13 12%
Agricultural and Biological Sciences 10 9%
Social Sciences 4 4%
Other 15 14%
Unknown 25 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2018.
All research outputs
#7,029,067
of 12,988,455 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#533
of 960 outputs
Outputs of similar age
#122,572
of 269,080 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#2
of 10 outputs
Altmetric has tracked 12,988,455 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 960 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,080 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.