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Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats

Overview of attention for article published in Acta cirurgica brasileira, April 2018
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Title
Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats
Published in
Acta cirurgica brasileira, April 2018
DOI 10.1590/s0102-865020180040000008
Pubmed ID
Authors

Erkan Yavuz, Gulcin Ercan, Onur Olgac Karagulle, Busra Yaprak Bayrak, Aytac Biricik, Candas Ercetin, Berk Gokcek, Hakan Yigitbas, Ramazan Kusaslan, Atilla Celik, Osman Bilgin Gulcicek

Abstract

To investigate the prophylactic and therapeutical effects of sildenafil in a model of acute radiation proctitis (ARP). All experimental procedures of this study was examined by histopathological, immunohistochemical and transmission electron microscopic analysis. Our histopathological evaluations indicated significant increases in lesion severity, cryptic apsis, cryptitis, cryptic distortion, reactive atypia and infiltration depth of the control (proctitis) group. While the prophylaxis group and the treatment group had significantly lower scores. High-dose group showed similar results as prophylaxis group. Histopathological findings of the prophylaxis group was more significant than the treatment group. Immunoreactivities of IL-1β, FGF-2, TNF- α and HIF-1α increased in the control group especially in the epithelial and cryptic regions. On the contrary, sildenafil application caused significant decreases of inflammatory markers in all treatment groups, specifically better results in the prophylaxis group. The sildenafil has anti-inflammatory effects on ARP, as well as protective effects against ARP and the protective effect of sildenafil surpasses its therapeutic effect histopathologically.

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Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 15%
Student > Bachelor 3 15%
Researcher 2 10%
Librarian 1 5%
Student > Postgraduate 1 5%
Other 0 0%
Unknown 10 50%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 6 30%
Medicine and Dentistry 4 20%
Unknown 10 50%