Title |
The roles of microRNAs in the regulation of tumor metastasis
|
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Published in |
Cell & Bioscience, June 2015
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DOI | 10.1186/s13578-015-0028-8 |
Pubmed ID | |
Authors |
Lei Zhou, Fan Liu, Xiaomin Wang, Gaoliang Ouyang |
Abstract |
MicroRNAs (miRNAs) are small noncoding regulatory RNAs that regulate gene expression post-transcriptionally by either inhibiting protein translation or degrading target mRNAs. The differential expression profiles of miRNAs in different types of cancers and in the multi-step process of tumor progression indicate that miRNAs are involved in tumor onset, growth and progression. Metastasis is the most common cause of cancer-related mortality. Current evidence demonstrates that aberrant miRNA expression promotes or inhibits tumor metastasis by modulating the expression of numerous target genes. Therefore, the identification of metastasis-related miRNAs and a better understanding of the complex functions of miRNAs in tumor metastasis will provide potential diagnostic and prognostic biomarkers, as well as therapeutic targets for clinical application. Here, we review the functions of miRNAs in the control of multiple steps of tumor metastasis. |
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Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
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Demographic breakdown
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Student > Master | 8 | 18% |
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Student > Bachelor | 3 | 7% |
Student > Doctoral Student | 2 | 4% |
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