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Application of CRISPR/Cas9 for biomedical discoveries

Overview of attention for article published in Cell & Bioscience, June 2015
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About this Attention Score

  • Among the highest-scoring outputs from this source (#45 of 381)
  • Good Attention Score compared to outputs of the same age (72nd percentile)

Mentioned by

twitter
6 tweeters

Citations

dimensions_citation
31 Dimensions

Readers on

mendeley
184 Mendeley
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Title
Application of CRISPR/Cas9 for biomedical discoveries
Published in
Cell & Bioscience, June 2015
DOI 10.1186/s13578-015-0027-9
Pubmed ID
Authors

Sean M. Riordan, Daniel P. Heruth, Li Q. Zhang, Shui Qing Ye

Abstract

The Clustered Regions of Interspersed Palindromic Repeats-Cas9 (CRISPR/Cas9), a viral defense system found in bacteria and archaea, has emerged as a tour de force genome editing tool. The CRISPR/Cas9 system is much easier to customize and optimize because the site selection for DNA cleavage is guided by a short sequence of RNA rather than an engineered protein as in the systems of zinc finger nucleases (ZFN), transcription activator-like effector nucleases (TALEN), and meganucleases. Although it still suffers from some off-target effects, the CRISPR/Cas9 system has been broadly and successfully applied for biomedical discoveries in a number of areas. In this review, we present a brief history and development of the CRISPR system and focus on the application of this genome editing technology for biomedical discoveries. We then present concise concluding remarks and future directions for this fast moving field.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Iran, Islamic Republic of 1 <1%
Finland 1 <1%
China 1 <1%
Spain 1 <1%
Brazil 1 <1%
Unknown 177 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 41 22%
Student > Bachelor 39 21%
Researcher 33 18%
Student > Ph. D. Student 28 15%
Student > Doctoral Student 10 5%
Other 20 11%
Unknown 13 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 86 47%
Biochemistry, Genetics and Molecular Biology 52 28%
Medicine and Dentistry 9 5%
Neuroscience 6 3%
Chemistry 5 3%
Other 11 6%
Unknown 15 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2016.
All research outputs
#4,046,676
of 14,536,182 outputs
Outputs from Cell & Bioscience
#45
of 381 outputs
Outputs of similar age
#63,092
of 233,176 outputs
Outputs of similar age from Cell & Bioscience
#1
of 3 outputs
Altmetric has tracked 14,536,182 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 381 research outputs from this source. They receive a mean Attention Score of 1.9. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,176 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them