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Mass Cytometric Functional Profiling of Acute Myeloid Leukemia Defines Cell-Cycle and Immunophenotypic Properties That Correlate with Known Responses to Therapy

Overview of attention for article published in Cancer Discovery, September 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

news
1 news outlet

Citations

dimensions_citation
91 Dimensions

Readers on

mendeley
139 Mendeley
citeulike
2 CiteULike
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Title
Mass Cytometric Functional Profiling of Acute Myeloid Leukemia Defines Cell-Cycle and Immunophenotypic Properties That Correlate with Known Responses to Therapy
Published in
Cancer Discovery, September 2015
DOI 10.1158/2159-8290.cd-15-0298
Pubmed ID
Authors

Gregory K. Behbehani, Nikolay Samusik, Zach B. Bjornson, Wendy J. Fantl, Bruno C. Medeiros, Garry P. Nolan

Abstract

Acute myeloid leukemia (AML) is characterized by a high relapse rate that has been attributed to the quiescence of leukemia stem cells (LSCs), which renders them resistant to chemotherapy. However, this hypothesis is largely supported by indirect evidence and fails to explain the large differences in relapse rates across AML subtypes. To address this, bone marrow aspirates from 41 AML patients and five healthy donors were analyzed by high-dimensional mass cytometry. All patients displayed immunophenotypic and intracellular signaling abnormalities within CD34+CD38low populations and several karyotype and genotype-specific surface marker patterns were identified. The immunophenotypic stem and early progenitor cell populations from patients with clinically favorable core-binding factor AML demonstrated a five-fold higher fraction of cells in S-phase compared to other AML samples. Conversely, LSCs in less clinically favorable FLT3-ITD AML exhibited dramatic reductions in S-phase fraction. Mass cytometry also allowed direct observation of the in vivo effects of cytotoxic chemotherapy.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 139 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Korea, Republic of 1 <1%
United Kingdom 1 <1%
Czechia 1 <1%
Unknown 134 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 36 26%
Student > Ph. D. Student 22 16%
Student > Master 17 12%
Other 15 11%
Student > Postgraduate 9 6%
Other 21 15%
Unknown 19 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 34 24%
Medicine and Dentistry 25 18%
Biochemistry, Genetics and Molecular Biology 24 17%
Immunology and Microbiology 17 12%
Chemistry 4 3%
Other 14 10%
Unknown 21 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2017.
All research outputs
#4,176,316
of 22,813,792 outputs
Outputs from Cancer Discovery
#1,175
of 3,656 outputs
Outputs of similar age
#53,718
of 266,791 outputs
Outputs of similar age from Cancer Discovery
#16
of 69 outputs
Altmetric has tracked 22,813,792 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,656 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.6. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,791 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.