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The p38 mitogen-activated protein kinase cascade modulates T helper type 17 differentiation and functionality in multiple sclerosis

Overview of attention for article published in Immunology, July 2015
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Title
The p38 mitogen-activated protein kinase cascade modulates T helper type 17 differentiation and functionality in multiple sclerosis
Published in
Immunology, July 2015
DOI 10.1111/imm.12497
Pubmed ID
Authors

Diletta Di Mitri, Manolo Sambucci, Maria Loiarro, Marco De Bardi, Elisabetta Volpe, Maria Teresa Cencioni, Claudio Gasperini, Diego Centonze, Claudio Sette, Arne N. Akbar, Giovanna Borsellino, Luca Battistini

Abstract

The p38 MAPK cascade is required for the induction of a Th17-mediated autoimmune response, which underlies the development and progression of several autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). However, the contribution of p38 phosphorylation to human Th cell differentiation has not been clarified yet. Here we demonstrate that the p38 signalling pathway is implicated in the generation of Th17 lymphocytes from human CD4(+) CD27(+) CD45RA(+) naive T cells, both in healthy donors and in patients affected by the relapsing remitting form of MS (RR-MS). Our data also indicate that p38 activation is essential for IL-17 release from central memory lymphocytes and committed Th17 cell clones. Furthermore, CD4(+) T cells isolated from RR-MS individuals display an altered responsiveness of the p38 cascade, resulting in increased p38 phosphorylation upon stimulation. These evidences suggest that the p38 signalling pathway, by modulating the Th17 differentiation and response, is involved in the pathogenesis of MS, and open new perspectives for the use of p38 inhibitors in the treatment of Th17-mediated autoimmune diseases. This article is protected by copyright. All rights reserved.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 20%
Student > Ph. D. Student 5 17%
Student > Master 3 10%
Student > Bachelor 2 7%
Professor > Associate Professor 2 7%
Other 6 20%
Unknown 6 20%
Readers by discipline Count As %
Medicine and Dentistry 9 30%
Agricultural and Biological Sciences 4 13%
Neuroscience 3 10%
Biochemistry, Genetics and Molecular Biology 2 7%
Psychology 2 7%
Other 4 13%
Unknown 6 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2015.
All research outputs
#9,860,950
of 12,348,212 outputs
Outputs from Immunology
#1,566
of 1,817 outputs
Outputs of similar age
#166,485
of 241,277 outputs
Outputs of similar age from Immunology
#45
of 54 outputs
Altmetric has tracked 12,348,212 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,817 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
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We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.