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Causes of genome instability: the effect of low dose chemical exposures in modern society

Overview of attention for article published in Carcinogenesis, June 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

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21 X users
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2 Facebook pages
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1 Google+ user

Citations

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160 Dimensions

Readers on

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336 Mendeley
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Title
Causes of genome instability: the effect of low dose chemical exposures in modern society
Published in
Carcinogenesis, June 2015
DOI 10.1093/carcin/bgv031
Pubmed ID
Authors

Sabine A S Langie, Gudrun Koppen, Daniel Desaulniers, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Amaya Azqueta, William H Bisson, Dustin G Brown, Gunnar Brunborg, Amelia K Charles, Tao Chen, Annamaria Colacci, Firouz Darroudi, Stefano Forte, Laetitia Gonzalez, Roslida A Hamid, Lisbeth E Knudsen, Luc Leyns, Adela Lopez de Cerain Salsamendi, Lorenzo Memeo, Chiara Mondello, Carmel Mothersill, Ann-Karin Olsen, Sofia Pavanello, Jayadev Raju, Emilio Rojas, Rabindra Roy, Elizabeth P Ryan, Patricia Ostrosky-Wegman, Hosni K Salem, A Ivana Scovassi, Neetu Singh, Monica Vaccari, Frederik J Van Schooten, Mahara Valverde, Jordan Woodrick, Luoping Zhang, Nik van Larebeke, Micheline Kirsch-Volders, Andrew R Collins

Abstract

Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to safeguard the genome's integrity, whether as a consequence of inherited defects or induced via exposure to environmental agents (chemicals, biological agents and radiation). Thus, genome instability can be defined as an enhanced tendency for the genome to acquire mutations; ranging from changes to the nucleotide sequence to chromosomal gain, rearrangements or loss. This review raises the hypothesis that in addition to known human carcinogens, exposure to low dose of other chemicals present in our modern society could contribute to carcinogenesis by indirectly affecting genome stability. The selected chemicals with their mechanisms of action proposed to indirectly contribute to genome instability are: heavy metals (DNA repair, epigenetic modification, DNA damage signaling, telomere length), acrylamide (DNA repair, chromosome segregation), bisphenol A (epigenetic modification, DNA damage signaling, mitochondrial function, chromosome segregation), benomyl (chromosome segregation), quinones (epigenetic modification) and nano-sized particles (epigenetic pathways, mitochondrial function, chromosome segregation, telomere length). The purpose of this review is to describe the crucial aspects of genome instability, to outline the ways in which environmental chemicals can affect this cancer hallmark and to identify candidate chemicals for further study. The overall aim is to make scientists aware of the increasing need to unravel the underlying mechanisms via which chemicals at low doses can induce genome instability and thus promote carcinogenesis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 336 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 <1%
India 1 <1%
United Kingdom 1 <1%
Mexico 1 <1%
Korea, Republic of 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 329 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 56 17%
Student > Ph. D. Student 48 14%
Student > Master 48 14%
Student > Bachelor 35 10%
Student > Doctoral Student 20 6%
Other 52 15%
Unknown 77 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 78 23%
Medicine and Dentistry 58 17%
Agricultural and Biological Sciences 40 12%
Environmental Science 19 6%
Pharmacology, Toxicology and Pharmaceutical Science 11 3%
Other 36 11%
Unknown 94 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2023.
All research outputs
#2,969,080
of 25,365,817 outputs
Outputs from Carcinogenesis
#317
of 4,907 outputs
Outputs of similar age
#35,509
of 270,387 outputs
Outputs of similar age from Carcinogenesis
#5
of 46 outputs
Altmetric has tracked 25,365,817 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,907 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,387 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.