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Occult HBV infection status among chronic hepatitis C and hemodialysis patients in Northeastern Egypt: regional and national overview

Overview of attention for article published in Revista da Sociedade Brasileira de Medicina Tropical, June 2015
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Title
Occult HBV infection status among chronic hepatitis C and hemodialysis patients in Northeastern Egypt: regional and national overview
Published in
Revista da Sociedade Brasileira de Medicina Tropical, June 2015
DOI 10.1590/0037-8682-0037-2015
Pubmed ID
Authors

Mohamed Mandour, Nader Nemr, Atef Shehata, Rania Kishk, Dahlia Badran, Nashaat Hawass

Abstract

Occult hepatitis B infection (OBI) is considered to be one of the major risks for patients suffering from end-stage renal disease (ESRD) on regular hemodialysis (HD) and patients with chronic hepatitis C virus (HCV) infection. This study compared the prevalence of OBI among these two high-risk groups in the Suez Canal region, Northeastern Egypt, to obtain a better national overview of the magnitude of OBI in this region. Serum samples were collected from 165 HD patients and 210 chronic HCV-infected patients. Anti-HCV antibody, hepatitis B surface antigen (HBsAg), total hepatitis B core (anti-HBc) antibody, and hepatitis B surface antibody (anti-HBs) were detected by enzyme-linked immunosorbent assay (ELISA). HCV RNA was detected using a quantitative real-time RT-PCR assay, and HBV was detected using a nested PCR. All patients were negative for HBsAg. A total of 49.1% and 25.2% of the patients in the HD and HCV groups, respectively, were anti-HBc-positive. In addition, more anti-HBs-positive patients were detected in the HD group compared to the HCV group (52.1% and 11.4%, respectively). Three cases were positive for HBV DNA in the HD group, while eighteen positive cases were detected in the HCV group. Both study groups showed significant differences in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level as well as anti-HBc, anti-HBs and HBV-DNA positivity. OBI was more prevalent among chronic HCV patients than HD patients in the Suez Canal region, Egypt, with rates of 8.5% and 1.8%, respectively. However, more precise assessment of this infection requires regular patient follow-up using HBV DNA detection methods.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 38 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 21%
Researcher 4 10%
Student > Postgraduate 4 10%
Other 3 8%
Student > Bachelor 3 8%
Other 11 28%
Unknown 6 15%
Readers by discipline Count As %
Medicine and Dentistry 19 49%
Agricultural and Biological Sciences 2 5%
Biochemistry, Genetics and Molecular Biology 2 5%
Nursing and Health Professions 2 5%
Social Sciences 2 5%
Other 5 13%
Unknown 7 18%