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Genome-wide essential gene identification in Streptococcus sanguinis

Overview of attention for article published in Scientific Reports, October 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

twitter
3 tweeters
wikipedia
1 Wikipedia page

Citations

dimensions_citation
69 Dimensions

Readers on

mendeley
87 Mendeley
citeulike
2 CiteULike
Title
Genome-wide essential gene identification in Streptococcus sanguinis
Published in
Scientific Reports, October 2011
DOI 10.1038/srep00125
Pubmed ID
Authors

Ping Xu, Xiuchun Ge, Lei Chen, Xiaojing Wang, Yuetan Dou, Jerry Z. Xu, Jenishkumar R. Patel, Victoria Stone, My Trinh, Karra Evans, Todd Kitten, Danail Bonchev, Gregory A. Buck

Abstract

A clear perception of gene essentiality in bacterial pathogens is pivotal for identifying drug targets to combat emergence of new pathogens and antibiotic-resistant bacteria, for synthetic biology, and for understanding the origins of life. We have constructed a comprehensive set of deletion mutants and systematically identified a clearly defined set of essential genes for Streptococcus sanguinis. Our results were confirmed by growing S. sanguinis in minimal medium and by double-knockout of paralogous or isozyme genes. Careful examination revealed that these essential genes were associated with only three basic categories of biological functions: maintenance of the cell envelope, energy production, and processing of genetic information. Our finding was subsequently validated in two other pathogenic streptococcal species, Streptococcus pneumoniae and Streptococcus mutans and in two other gram-positive pathogens, Bacillus subtilis and Staphylococcus aureus. Our analysis has thus led to a simplified model that permits reliable prediction of gene essentiality.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 3%
United States 2 2%
Brazil 1 1%
Unknown 81 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 34%
Researcher 22 25%
Student > Master 11 13%
Student > Bachelor 6 7%
Unspecified 5 6%
Other 13 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 42 48%
Biochemistry, Genetics and Molecular Biology 15 17%
Unspecified 9 10%
Medicine and Dentistry 6 7%
Immunology and Microbiology 4 5%
Other 11 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2015.
All research outputs
#807,687
of 4,728,550 outputs
Outputs from Scientific Reports
#3,250
of 13,273 outputs
Outputs of similar age
#10,804
of 70,235 outputs
Outputs of similar age from Scientific Reports
#22
of 92 outputs
Altmetric has tracked 4,728,550 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,273 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.0. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,235 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.