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Immunomodulation of enteric neural function in irritable bowel syndrome

Overview of attention for article published in World Journal of Gastroenterology, January 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

twitter
5 tweeters
patent
2 patents

Citations

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27 Dimensions

Readers on

mendeley
102 Mendeley
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Title
Immunomodulation of enteric neural function in irritable bowel syndrome
Published in
World Journal of Gastroenterology, January 2015
DOI 10.3748/wjg.v21.i24.7362
Pubmed ID
Authors

Dervla O’Malley

Abstract

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder which is characterised by symptoms such as bloating, altered bowel habit and visceral pain. It's generally accepted that miscommunication between the brain and gut underlies the changes in motility, absorpto-secretory function and pain sensitivity associated with IBS. However, partly due to the lack of disease-defining biomarkers, understanding the aetiology of this complex and multifactorial disease remains elusive. Anecdotally, IBS patients have noted that periods of stress can result in symptom flares and many patients exhibit co-morbid stress-related mood disorders such as anxiety and depression. However, in addition to psychosocial stressors, infection-related stress has also been linked with the initiation, persistence and severity of symptom flares. Indeed, prior gastrointestinal infection is one of the strongest predictors of developing IBS. Despite a lack of overt morphological inflammation, the importance of immune factors in the pathophysiology of IBS is gaining acceptance. Subtle changes in the numbers of mucosal immune cell infiltrates and elevated levels of circulating pro-inflammatory cytokines have been reproducibly demonstrated in IBS populations. Moreover, these immune mediators directly affect neural signalling. An exciting new area of research is the role of luminal microbiota in the modulation of neuro-immune signalling, resulting in local changes in gastrointestinal function and alterations in central neural functioning. Progress in this area has begun to unravel some of the complexities of neuroimmune and neuroendocrine interactions and how these molecular exchanges contribute to GI dysfunction.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 <1%
Brazil 1 <1%
Unknown 100 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 18 18%
Student > Master 17 17%
Student > Ph. D. Student 13 13%
Researcher 12 12%
Student > Doctoral Student 7 7%
Other 18 18%
Unknown 17 17%
Readers by discipline Count As %
Medicine and Dentistry 25 25%
Biochemistry, Genetics and Molecular Biology 12 12%
Psychology 12 12%
Agricultural and Biological Sciences 10 10%
Neuroscience 6 6%
Other 16 16%
Unknown 21 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2019.
All research outputs
#4,587,384
of 17,359,532 outputs
Outputs from World Journal of Gastroenterology
#1,166
of 6,004 outputs
Outputs of similar age
#60,121
of 237,906 outputs
Outputs of similar age from World Journal of Gastroenterology
#6
of 57 outputs
Altmetric has tracked 17,359,532 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 6,004 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,906 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.