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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Adding left atrial appendage closure to open heart surgery provides protection from ischemic brain injury six years after surgery independently of atrial fibrillation history: the LAACS randomized study
|
|---|---|
| Published in |
Journal of Cardiothoracic Surgery, May 2018
|
| DOI | 10.1186/s13019-018-0740-7 |
| Pubmed ID | |
| Authors |
Jesper Park-Hansen, Susanne J.V. Holme, Akhmadjon Irmukhamedov, Christian L. Carranza, Anders M. Greve, Gina Al-Farra, Robert G. C. Riis, Brian Nilsson, Johan S.R. Clausen, Anne S. Nørskov, Christina R. Kruuse, Egill Rostrup, Helena Dominguez |
| Abstract |
Open heart surgery is associated with high occurrence of atrial fibrillation (AF), subsequently increasing the risk of post-operative ischemic stroke. Concomitant with open heart surgery, a cardiac ablation procedure is commonly performed in patients with known AF, often followed by left atrial appendage closure with surgery (LAACS). However, the protective effect of LAACS on the risk of cerebral ischemia following cardiac surgery remains controversial. We have studied whether LAACS in addition to open heart surgery protects against post-operative ischemic brain injury regardless of a previous AF diagnosis. One hundred eighty-seven patients scheduled for open heart surgery were enrolled in a prospective, open-label clinical trial and randomized to concomitant LAACS vs. standard care. Randomization was stratified by usage of oral anticoagulation (OAC) planned to last at least 3 months after surgery. The primary endpoint was a composite of post-operative symptomatic ischemic stroke, transient ischemic attack or imaging findings of silent cerebral ischemic (SCI) lesions. During a mean follow-up of 3.7 years, 14 (16%) primary events occurred among patients receiving standard surgery vs. 5 (5%) in the group randomized to additional LAACS (hazard ratio 0.3; 95% CI: 0.1-0.8, p = 0.02). In per protocol analysis (n = 141), 14 (18%) primary events occurred in the control group vs. 4 (6%) in the LAACS group (hazard ratio 0.3; 95% CI: 0.1-1.0, p = 0.05). In a real-world setting, LAACS in addition to elective open-heart surgery was associated with lower risk of post-operative ischemic brain injury. The protective effect was not conditional on AF/OAC status at baseline. LAACS study, clinicaltrials.gov NCT02378116 , March 4th 2015, retrospectively registered. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 89 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 11% |
| Student > Ph. D. Student | 9 | 10% |
| Researcher | 8 | 9% |
| Other | 8 | 9% |
| Student > Doctoral Student | 6 | 7% |
| Other | 18 | 20% |
| Unknown | 30 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 38 | 43% |
| Nursing and Health Professions | 4 | 4% |
| Business, Management and Accounting | 3 | 3% |
| Materials Science | 2 | 2% |
| Immunology and Microbiology | 2 | 2% |
| Other | 8 | 9% |
| Unknown | 32 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2018.
All research outputs
#17,964,768
of 23,070,218 outputs
Outputs from Journal of Cardiothoracic Surgery
#546
of 1,250 outputs
Outputs of similar age
#238,878
of 330,223 outputs
Outputs of similar age from Journal of Cardiothoracic Surgery
#16
of 57 outputs
Altmetric has tracked 23,070,218 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,250 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,223 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.