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Chromosome territory repositioning induced by PHA-activation of lymphocytes: A 2D and 3D appraisal

Overview of attention for article published in Molecular Cytogenetics, July 2015
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Title
Chromosome territory repositioning induced by PHA-activation of lymphocytes: A 2D and 3D appraisal
Published in
Molecular Cytogenetics, July 2015
DOI 10.1186/s13039-015-0146-3
Pubmed ID
Authors

Dimitrios Ioannou, Lakshmi Kandukuri, Joe Leigh Simpson, Helen Ghislaine Tempest

Abstract

Genomes and by extension chromosome territories (CTs) in a variety of organisms exhibit nonrandom organization within interphase nuclei. CTs are susceptible to movement upon induction by a variety of stimuli, including: cell differentiation, growth factors, genotoxic agents, proliferating status, and stimulants that induce novel transcription profiles. These findings suggest nuclear architecture can undergo reorganization, providing support for a functional significance of CT organization. The effect of the initiation of transcription on global scale chromatin architecture has been underexplored. This study investigates the organization of all 24 human chromosomes in lymphocytes from two individuals in resting and phytohaemagglutinin activated lymphocytes using 2D and 3D approaches. The radial organization of CTs in lymphocytes in both resting and activated lymphocytes follows a gene-density pattern. However, CT organization in activated nuclei appears less constrained exhibiting a more random organization. We report differences in the spatial relationship between homologous and heterologous CTs in activated nuclei. In addition, a reproducible radial hierarchy of CTs was identified and evidence of a CT repositioning was observed in activated nuclei using both 2D and 3D approaches. Alterations between resting and activated lymphocytes could be adaptation of CTs to the new transcription profile and possibly the formation of new neighborhoods of interest or interaction of CTs with nuclear landmarks. The increased distances between homologous and heterologous CTs in activated lymphocytes could be a reflection of a defensive mechanism to reduce potential interaction to prevent any structural chromosome abnormalities (e.g. translocations) as a result of DNA damage that increases during lymphocyte activation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 30%
Researcher 6 20%
Professor 4 13%
Student > Master 3 10%
Student > Bachelor 2 7%
Other 4 13%
Unknown 2 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 40%
Biochemistry, Genetics and Molecular Biology 8 27%
Immunology and Microbiology 3 10%
Computer Science 2 7%
Nursing and Health Professions 1 3%
Other 1 3%
Unknown 3 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2015.
All research outputs
#17,765,638
of 22,816,807 outputs
Outputs from Molecular Cytogenetics
#210
of 400 outputs
Outputs of similar age
#176,562
of 262,956 outputs
Outputs of similar age from Molecular Cytogenetics
#11
of 18 outputs
Altmetric has tracked 22,816,807 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 400 research outputs from this source. They receive a mean Attention Score of 2.4. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,956 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.