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Biodegradable PEG-Based Amphiphilic Block Copolymers for Tissue Engineering Applications

Overview of attention for article published in ACS Biomaterials Science & Engineering, June 2015
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  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

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1 X user
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3 patents

Citations

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145 Dimensions

Readers on

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183 Mendeley
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Title
Biodegradable PEG-Based Amphiphilic Block Copolymers for Tissue Engineering Applications
Published in
ACS Biomaterials Science & Engineering, June 2015
DOI 10.1021/acsbiomaterials.5b00122
Pubmed ID
Authors

Artem B. Kutikov, Jie Song

Abstract

Biodegradable tissue engineering scaffolds have great potential for delivering cells/therapeutics and supporting tissue formation. Polyesters, the most extensively investigated biodegradable synthetic polymers, are not ideally suited for diverse tissue engineering applications due to limitations associated with their hydrophobicity. This review discusses the design and applications of amphiphilic block copolymer scaffolds integrating hydrophilic poly(ethylene glycol) (PEG) blocks with hydrophobic polyesters. Specifically, we highlight how the addition of PEG results in striking changes to the physical properties (swelling, degradation, mechanical, handling) and biological performance (protein & cell adhesion) of the degradable synthetic scaffolds in vitro. We then perform a critical review of how these in vitro characteristics translate to the performance of biodegradable amphiphilic block copolymer-based scaffolds in the repair of a variety of tissues in vivo including bone, cartilage, skin, and spinal cord/nerve. We conclude the review with recommendations for future optimizations in amphiphilic block copolymer design and the need for better-controlled in vivo studies to reveal the true benefits of the amphiphilic synthetic tissue scaffolds.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 183 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
France 1 <1%
Unknown 181 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 50 27%
Student > Master 27 15%
Researcher 22 12%
Student > Bachelor 14 8%
Student > Doctoral Student 10 5%
Other 18 10%
Unknown 42 23%
Readers by discipline Count As %
Chemistry 49 27%
Materials Science 20 11%
Engineering 16 9%
Chemical Engineering 14 8%
Agricultural and Biological Sciences 9 5%
Other 32 17%
Unknown 43 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2022.
All research outputs
#7,960,693
of 25,377,790 outputs
Outputs from ACS Biomaterials Science & Engineering
#499
of 1,580 outputs
Outputs of similar age
#88,330
of 281,077 outputs
Outputs of similar age from ACS Biomaterials Science & Engineering
#8
of 22 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,580 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,077 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.