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Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography

Overview of attention for article published in Nature Communications, July 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

news
4 news outlets
twitter
41 tweeters
facebook
1 Facebook page

Readers on

mendeley
76 Mendeley
Title
Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography
Published in
Nature Communications, July 2015
DOI 10.1038/ncomms8495
Pubmed ID
Authors

Agnese Irkle, Alex T. Vesey, David Y. Lewis, Jeremy N. Skepper, Joseph L. E. Bird, Marc R. Dweck, Francis R. Joshi, Ferdia A. Gallagher, Elizabeth A. Warburton, Martin R. Bennett, Kevin M. Brindle, David E. Newby, James H. Rudd, Anthony P. Davenport, Irkle, Agnese, Vesey, Alex T, Lewis, David Y, Skepper, Jeremy N, Bird, Joseph L E, Dweck, Marc R, Joshi, Francis R, Gallagher, Ferdia A, Warburton, Elizabeth A, Bennett, Martin R, Brindle, Kevin M, Newby, David E, Rudd, James H, Davenport, Anthony P

Abstract

Vascular calcification is a complex biological process that is a hallmark of atherosclerosis. While macrocalcification confers plaque stability, microcalcification is a key feature of high-risk atheroma and is associated with increased morbidity and mortality. Positron emission tomography and X-ray computed tomography (PET/CT) imaging of atherosclerosis using (18)F-sodium fluoride ((18)F-NaF) has the potential to identify pathologically high-risk nascent microcalcification. However, the precise molecular mechanism of (18)F-NaF vascular uptake is still unknown. Here we use electron microscopy, autoradiography, histology and preclinical and clinical PET/CT to analyse (18)F-NaF binding. We show that (18)F-NaF adsorbs to calcified deposits within plaque with high affinity and is selective and specific. (18)F-NaF PET/CT imaging can distinguish between areas of macro- and microcalcification. This is the only currently available clinical imaging platform that can non-invasively detect microcalcification in active unstable atherosclerosis. The use of (18)F-NaF may foster new approaches to developing treatments for vascular calcification.

Twitter Demographics

The data shown below were collected from the profiles of 41 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 3%
United Kingdom 1 1%
United States 1 1%
Pakistan 1 1%
Netherlands 1 1%
Unknown 70 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 32%
Researcher 15 20%
Student > Bachelor 12 16%
Student > Master 5 7%
Other 4 5%
Other 16 21%
Readers by discipline Count As %
Medicine and Dentistry 39 51%
Agricultural and Biological Sciences 9 12%
Engineering 6 8%
Unspecified 5 7%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Other 13 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 56. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2016.
All research outputs
#181,869
of 8,699,779 outputs
Outputs from Nature Communications
#3,206
of 14,297 outputs
Outputs of similar age
#6,047
of 228,968 outputs
Outputs of similar age from Nature Communications
#115
of 725 outputs
Altmetric has tracked 8,699,779 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,297 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 44.8. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,968 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 725 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.