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Danger in the reef: Proteome, toxicity, and neutralization of the venom of the olive sea snake, Aipysurus laevis

Overview of attention for article published in Toxicon, December 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#31 of 2,130)
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
3 news outlets
blogs
1 blog
twitter
1 tweeter
facebook
1 Facebook page

Citations

dimensions_citation
23 Dimensions

Readers on

mendeley
42 Mendeley
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Title
Danger in the reef: Proteome, toxicity, and neutralization of the venom of the olive sea snake, Aipysurus laevis
Published in
Toxicon, December 2015
DOI 10.1016/j.toxicon.2015.07.008
Pubmed ID
Authors

Andreas H. Laustsen, José María Gutiérrez, Arne R. Rasmussen, Mikael Engmark, Peter Gravlund, Kate L. Sanders, Brian Lohse, Bruno Lomonte

Abstract

Four specimens of the olive sea snake, Aipysurus laevis, were collected off the coast of Western Australia, and the venom proteome was characterized and quantitatively estimated by RP-HPLC, SDS-PAGE, and MALDI-TOF-TOF analyses. A. laevis venom is remarkably simple and consists of phospholipases A2 (71.2%), three-finger toxins (3FTx; 25.3%), cysteine-rich secretory proteins (CRISP; 2.5%), and traces of a complement control module protein (CCM; 0.2%). Using a Toxicity Score, the most lethal components were determined to be short neurotoxins. Whole venom had an intravenous LD50 of 0.07 mg/kg in mice and showed a high phospholipase A2 activity, but no proteinase activity in vitro. Preclinical assessment of neutralization and ELISA immunoprofiling showed that BioCSL Sea Snake Antivenom was effective in cross-neutralizing A. laevis venom with an ED50 of 821 μg venom per mL antivenom, with a binding preference towards short neurotoxins, due to the high degree of conservation between short neurotoxins from A. laevis and Enhydrina schistosa venom. Our results point towards the possibility of developing recombinant antibodies or synthetic inhibitors against A. laevis venom due to its simplicity.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 2%
Australia 1 2%
Unknown 40 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 26%
Student > Ph. D. Student 8 19%
Student > Bachelor 8 19%
Researcher 5 12%
Lecturer 2 5%
Other 6 14%
Unknown 2 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 43%
Biochemistry, Genetics and Molecular Biology 6 14%
Chemistry 3 7%
Environmental Science 2 5%
Medicine and Dentistry 2 5%
Other 5 12%
Unknown 6 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2016.
All research outputs
#463,789
of 12,269,218 outputs
Outputs from Toxicon
#31
of 2,130 outputs
Outputs of similar age
#12,453
of 236,594 outputs
Outputs of similar age from Toxicon
#2
of 30 outputs
Altmetric has tracked 12,269,218 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,130 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,594 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.