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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Sparse whole-genome sequencing identifies two loci for major depressive disorder
|
|---|---|
| Published in |
Nature, July 2015
|
| DOI | 10.1038/nature14659 |
| Pubmed ID | |
| Abstract |
Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis. To date, no robustly replicated genetic loci have been identified, despite analysis of more than 9,000 cases. Here, using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, we identified, and subsequently replicated in an independent sample, two loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene (P = 2.53 × 10(-10)), the other in an intron of the LHPP gene (P = 6.45 × 10(-12)). Analysis of 4,509 cases with a severe subtype of MDD, melancholia, yielded an increased genetic signal at the SIRT1 locus. We attribute our success to the recruitment of relatively homogeneous cases with severe illness. |
X Demographics
The data shown below were collected from the profiles of 197 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 50 | 25% |
| United Kingdom | 23 | 12% |
| Spain | 7 | 4% |
| France | 4 | 2% |
| Australia | 4 | 2% |
| Ireland | 3 | 2% |
| Netherlands | 3 | 2% |
| Canada | 3 | 2% |
| Germany | 3 | 2% |
| Other | 23 | 12% |
| Unknown | 74 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 113 | 57% |
| Scientists | 62 | 31% |
| Practitioners (doctors, other healthcare professionals) | 13 | 7% |
| Science communicators (journalists, bloggers, editors) | 9 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 926 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | <1% |
| United Kingdom | 7 | <1% |
| Germany | 3 | <1% |
| Italy | 2 | <1% |
| Denmark | 2 | <1% |
| Spain | 2 | <1% |
| Brazil | 2 | <1% |
| Ireland | 1 | <1% |
| Austria | 1 | <1% |
| Other | 8 | <1% |
| Unknown | 889 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 181 | 20% |
| Researcher | 167 | 18% |
| Student > Master | 115 | 12% |
| Student > Bachelor | 104 | 11% |
| Student > Doctoral Student | 44 | 5% |
| Other | 165 | 18% |
| Unknown | 150 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 183 | 20% |
| Biochemistry, Genetics and Molecular Biology | 130 | 14% |
| Neuroscience | 98 | 11% |
| Medicine and Dentistry | 96 | 10% |
| Psychology | 85 | 9% |
| Other | 136 | 15% |
| Unknown | 198 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 350. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2024.
All research outputs
#94,911
of 25,846,867 outputs
Outputs from Nature
#6,615
of 98,923 outputs
Outputs of similar age
#883
of 277,367 outputs
Outputs of similar age from Nature
#123
of 962 outputs
Altmetric has tracked 25,846,867 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,923 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.8. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,367 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 962 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.