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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma
|
|---|---|
| Published in |
Clinical Cancer Research, November 2015
|
| DOI | 10.1158/1078-0432.ccr-14-2744 |
| Pubmed ID | |
| Authors |
Konstantin Agelopoulos, Günther H.S. Richter, Eva Schmidt, Uta Dirksen, Kristina von Heyking, Benjamin Moser, Hans-Ulrich Klein, Udo Kontny, Martin Dugas, Kathrin Poos, Eberhard Korsching, Thorsten Buch, Matthias Weckesser, Isabell Schulze, Regina Besoke, Anika Witten, Monika Stoll, Gabriele Köhler, Wolfgang Hartmann, Eva Wardelmann, Claudia Rossig, Daniel Baumhoer, Heribert Jürgens, Stefan Burdach, Wolfgang E. Berdel, Carsten Müller-Tidow |
| Abstract |
A low mutation rate seems a general feature of pediatric cancers, in par-ticular in oncofusion gene driven tumors. Genetically, Ewing sarcoma (ES) is de-fined by balanced chromosomal EWS/ETS translocations, which give rise to onco-genic chimeric proteins (EWS-ETS). Other contributing somatic mutations involved in disease development have only been observed at low frequency. Tumor samples of 116 Ewing sarcoma (ES) patients were analyzed here. Whole Genome Sequencing was performed on two patients with normal, primary and relapsed tissue. Whole Exome Sequencing was performed on 50 ES and 22 matched normal tissues. A discovery data set of 14 of these tu-mor/normal pairs identified 232 somatic mutations. Recurrent non-synonymous mu-tations were validated in the 36 remaining exomes. Transcriptome analysis was per-formed in a subset of 14/50 ES and DNA copy number gain and expression of FGFR1 in 63/116 ES. Relapsed tumors consistently showed a 2- to 3-fold increased number of mutations. We identified several recurrently mutated genes at low frequency (ANKRD30A, CCDC19, KIAA0319, KIAA1522, LAMB4, SLFN11, STAG2, TP53, UNC80, ZNF98). An oncogenic fibroblast growth factor receptor 1 (FGFR1) mutation (N546K) was detected, and the FGFR1 locus frequently showed copy number gain (31.7%) in primary tumors. Furthermore, high-level FGFR1 expression was noted as a characteristic feature of ES. RNA-Interference of FGFR1 expression in ES lines blocked proliferation and completely suppressed xenograft tumor growth. FGFR1 TKI inhibitor therapy in a patient with ES relapse significantly reduced 18-FDG-PET activity. FGFR1 may constitute a promising target for novel therapeutic ap-proaches in ES. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 10% |
| Korea, Republic of | 1 | 10% |
| United Kingdom | 1 | 10% |
| United States | 1 | 10% |
| Unknown | 6 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 60% |
| Science communicators (journalists, bloggers, editors) | 2 | 20% |
| Scientists | 1 | 10% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 3% |
| Switzerland | 1 | 2% |
| Unknown | 62 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 22% |
| Student > Master | 12 | 18% |
| Student > Ph. D. Student | 8 | 12% |
| Student > Bachelor | 5 | 8% |
| Student > Doctoral Student | 5 | 8% |
| Other | 8 | 12% |
| Unknown | 13 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 19 | 29% |
| Medicine and Dentistry | 14 | 22% |
| Agricultural and Biological Sciences | 9 | 14% |
| Immunology and Microbiology | 2 | 3% |
| Computer Science | 2 | 3% |
| Other | 7 | 11% |
| Unknown | 12 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2016.
All research outputs
#2,075,667
of 22,817,213 outputs
Outputs from Clinical Cancer Research
#1,691
of 12,595 outputs
Outputs of similar age
#31,934
of 284,427 outputs
Outputs of similar age from Clinical Cancer Research
#18
of 166 outputs
Altmetric has tracked 22,817,213 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,595 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,427 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 166 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.