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Antiviral activity of arbidol, a broad-spectrum drug for use against respiratory viruses, varies according to test conditions

Overview of attention for article published in Journal of Medical Virology, October 2011
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Title
Antiviral activity of arbidol, a broad-spectrum drug for use against respiratory viruses, varies according to test conditions
Published in
Journal of Medical Virology, October 2011
DOI 10.1002/jmv.22234
Pubmed ID
Authors

Megan J. Brooks, Elena I. Burtseva, Philip J. Ellery, Glenn A. Marsh, Andrew M. Lew, Anatoly N. Slepushkin, Suzanne M. Crowe, Gregory A. Tannock

Abstract

The therapeutic activity of arbidol was investigated against representatives of seven different virus families. Its 50% median effective concentration (EC(50) ) was 0.22-11.8 µg/ml (0.41-22 nM). Therapeutic indices of 91 were obtained for type 1 poliovirus and 1.9-8.5 for influenza A and B, human paramyxo-3, avian infectious bronchitis-, and Marek's disease viruses. Arbidol was more inhibitory for influenza A/Aichi/2/68 (H3N2) virus than rimantadine or amantadine (EC(50) 10 vs. >15 and >31.6 µg/ml); greater inhibition occurred when end-points were expressed as TCID(50) s. For respiratory syncytial virus (RSV), a reduction in plaque size but not number was observed. However, when the drug was added to infected cultures (≥5 µg/ml), a 3-log reduction in titer occurred. Arbidol did not inhibit directly influenza A/Aichi/2/68 hemagglutinin (HA) or neuraminidase (NA) activity, but inhibition of fusion between the viral envelope and chicken red blood cells occurred when added at 0.1 µg/ml prior to infection. Arbidol induced changes to viral mRNA synthesis of the PB2, PA, NP, NA, and NS genes in MDCK cultures infected with influenza A/PR/8/34. There was no indirect evidence of enhancement of interferon-α by arbidol following infection with A/Aichi/2/68. Arbidol neither reduced lung viral titers nor caused a significant reduction of lung consolidation in BALB/c mice after administration by the oral and intraperitoneal (i.p.) routes and intranasal challenge with influenza A/Aichi/2/68. A small reduction in lung consolidation, but not viral titer, occurred after i.p. administration and subsequent challenge with RSV. The results indicate the potential of arbidol as a broad-spectrum respiratory antiviral drug.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 3%
Denmark 1 3%
United States 1 3%
Unknown 28 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 26%
Unspecified 6 19%
Student > Master 5 16%
Student > Ph. D. Student 5 16%
Other 2 6%
Other 5 16%
Readers by discipline Count As %
Unspecified 8 26%
Agricultural and Biological Sciences 7 23%
Medicine and Dentistry 5 16%
Veterinary Science and Veterinary Medicine 2 6%
Chemistry 2 6%
Other 7 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2011.
All research outputs
#7,610,916
of 12,180,504 outputs
Outputs from Journal of Medical Virology
#1,871
of 2,617 outputs
Outputs of similar age
#59,909
of 103,698 outputs
Outputs of similar age from Journal of Medical Virology
#13
of 39 outputs
Altmetric has tracked 12,180,504 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,617 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,698 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.