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Red meat allergic patients have a selective IgE response to the α-Gal glycan

Overview of attention for article published in Allergy, August 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
3 news outlets
twitter
12 tweeters
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

dimensions_citation
18 Dimensions

Readers on

mendeley
35 Mendeley
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Title
Red meat allergic patients have a selective IgE response to the α-Gal glycan
Published in
Allergy, August 2015
DOI 10.1111/all.12695
Pubmed ID
Authors

D. Apostolovic, T. A. T. Tran, S. Sánchez-Vidaurre, T. Cirkovic Velickovic, M. Starkhammar, C. Hamsten, M. van Hage

Abstract

Galactose-α-1,3-galactose (α-Gal) is a mammalian carbohydrate with significance in a novel type of food allergy. Patients with IgE against α-Gal report severe allergic symptoms 3 to 6 hours after red meat consumption. We investigated whether IgE from red meat allergic patients recognize other mammalian glycans than α-Gal or glycans from the plant kingdom and insects of importance in allergy. We found that all 24 red meat allergic patients neither had an IgE antibody response against the other abundant mammalian glycan N-glycolylneuraminic acid nor against cross-reactive carbohydrate determinants from plant or venom sources (nCup a 1, nArt v 1 and MUXF3). Deglycosylation of an α-Gal containing protein, bovine thyroglobulin, significantly reduced the IgE response. In conclusion we show that red meat allergic patients have a selective IgE response to the α-Gal glycan found in red meat. Other common glycans reactive in allergic disease are not targets of red meat allergic patients' IgE. This article is protected by copyright. All rights reserved.

Twitter Demographics

The data shown below were collected from the profiles of 12 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ireland 1 3%
Unknown 34 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 34%
Researcher 6 17%
Student > Master 4 11%
Other 2 6%
Student > Postgraduate 2 6%
Other 6 17%
Unknown 3 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 34%
Medicine and Dentistry 7 20%
Biochemistry, Genetics and Molecular Biology 3 9%
Chemistry 3 9%
Nursing and Health Professions 1 3%
Other 3 9%
Unknown 6 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2018.
All research outputs
#883,934
of 18,438,151 outputs
Outputs from Allergy
#260
of 4,401 outputs
Outputs of similar age
#13,922
of 241,369 outputs
Outputs of similar age from Allergy
#5
of 50 outputs
Altmetric has tracked 18,438,151 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,401 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,369 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.