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Piper aduncum against Haemonchus contortus isolates: cross resistance and the research of natural bioactive compounds

Overview of attention for article published in Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, December 2016
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Title
Piper aduncum against Haemonchus contortus isolates: cross resistance and the research of natural bioactive compounds
Published in
Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, December 2016
DOI 10.1590/s1984-29612016073
Pubmed ID
Authors

Yousmel Alemán Gaínza, Rafaela Regina Fantatto, Francisco Celio Maia Chaves, Humberto Ribeiro Bizzo, Sérgio Novita Esteves, Ana Carolina de Souza Chagas

Abstract

The anthelminthic activity of the essential oil (EO) of Piper aduncum L. was tested in vitro on eggs and larvae of resistant (Embrapa2010) and susceptible (McMaster) isolates of Haemonchus contortus. The EO was obtained by steam distillation and its components identified by chromatography. EO concentrations of 12.5 to 0.02 mg/mL were used in the egg hatch test (EHT) and concentrations of 3.12 to 0.01 mg/mL in the larval development test (LDT). Inhibition concentrations (IC) were determined by the SAS Probit procedure, and significant differences assessed by ANOVA followed by Tukey's test. In the EHT, the IC50 for the susceptible isolate was 5.72 mg/mL. In the LDT, the IC50 and IC90 were, respectively, 0.10 mg/mL and 0.34 mg/mL for the susceptible isolate, and 0.22 mg/mL and 0.51 mg/mL for the resistant isolate. The EO (dillapiole 76.2%) was highly efficacious on phase L1. Due to the higher ICs obtained for the resistant isolate, it was raised the hypothesis that dillapiole may have a mechanism of action that resembles those of other anthelmintic compounds. We further review and discuss studies, especially those conducted in Brazil, that quantified the major constituents of P. aduncum-derived EO.

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Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Professor 1 5%
Student > Master 1 5%
Unknown 19 90%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 10%
Unknown 19 90%