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Eg5 orchestrates porcine oocyte maturational progression by maintaining meiotic organelle arrangement

Overview of attention for article published in Cell Division, May 2018
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4 tweeters

Citations

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4 Dimensions

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8 Mendeley
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Title
Eg5 orchestrates porcine oocyte maturational progression by maintaining meiotic organelle arrangement
Published in
Cell Division, May 2018
DOI 10.1186/s13008-018-0037-1
Pubmed ID
Authors

Yan Xie, Minghui Cheng, Shan Lu, Qilong Yuan, Dongyu Yang, Ying Chen, Chen Pan, Yurong Qiu, Bo Xiong

Abstract

Kinesin superfamily proteins are microtubule-based molecular motors essential for the intracellular transport of various cargos, including organelles, proteins, and RNAs. However, their exact roles during mammalian oocyte meiosis have not been fully clarified. Herein, we investigated the critical events during porcine oocyte meiotic maturation with the treatment of Eg5-specific inhibitor monastrol. We found that Eg5 inhibition resulted in oocyte meiotic failure by displaying the poor expansion of cumulus cells and reduced rate of polar body extrusion. In the meantime, the spindle assembly and chromosome alignment were compromised, accompanied by the decreased level of acetylated α-tubulin, indicative of less stable microtubules. Impaired actin dynamics and mitochondria integrity were also observed in Eg5-inhibited oocytes. Additionally, inhibition of Eg5 caused the abnormal distribution of cortical granules and ovastacin, a cortical granule component, potentially leading to the fertilization failure. Our findings reveal that Eg5 possesses an important function in porcine oocyte meiotic progression by regulating the organelle dynamics and arrangement.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 25%
Researcher 2 25%
Student > Ph. D. Student 1 13%
Professor 1 13%
Unspecified 1 13%
Other 0 0%
Unknown 1 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 38%
Agricultural and Biological Sciences 2 25%
Unspecified 1 13%
Veterinary Science and Veterinary Medicine 1 13%
Unknown 1 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2018.
All research outputs
#7,228,060
of 13,044,081 outputs
Outputs from Cell Division
#38
of 82 outputs
Outputs of similar age
#129,217
of 271,461 outputs
Outputs of similar age from Cell Division
#1
of 2 outputs
Altmetric has tracked 13,044,081 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 82 research outputs from this source. They receive a mean Attention Score of 3.1. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,461 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them