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1 Versus 2-cm Excision Margins for pT2-pT4 Primary Cutaneous Melanoma (MelMarT): A Feasibility Study

Overview of attention for article published in Annals of Surgical Oncology, May 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

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Title
1 Versus 2-cm Excision Margins for pT2-pT4 Primary Cutaneous Melanoma (MelMarT): A Feasibility Study
Published in
Annals of Surgical Oncology, May 2018
DOI 10.1245/s10434-018-6470-1
Pubmed ID
Authors

Marc D. Moncrieff, David Gyorki, Robyn Saw, Andrew J. Spillane, Howard Peach, Deemesh Oudit, Jenny Geh, Peter Dziewulski, Ewan Wilson, Paolo Matteucci, Rowan Pritchard-Jones, Roger Olofsson Bagge, Frances C. Wright, Nic Crampton, Oliver Cassell, Navid Jallali, Adam Berger, John Kelly, Stephen Hamilton, Amer Durrani, Serigne Lo, Elizabeth Paton, Michael A. Henderson

Abstract

There is a lack of consensus regarding optimal surgical excision margins for primary cutaneous melanoma > 1 mm in Breslow thickness (BT). A narrower surgical margin is expected to be associated with lower morbidity, improved quality of life (QoL), and reduced cost. We report the results of a pilot international study (MelMarT) comparing a 1 versus 2-cm surgical margin for patients with primary melanoma > 1 mm in BT. This phase III, multicentre trial [NCT02385214] administered by the Australia & New Zealand Medical Trials Group (ANZMTG 03.12) randomised patients with a primary cutaneous melanoma > 1 mm in BT to a 1 versus 2-cm wide excision margin to be performed with sentinel lymph node biopsy. Surgical closure technique was at the discretion of the treating surgeon. Patients' QoL was measured (FACT-M questionnaire) at baseline, 3, 6, and 12 months after randomisation. Between January 2015 and June 2016, 400 patients were randomised from 17 centres in 5 countries. A total of 377 patients were available for analysis. Primary melanomas were located on the trunk (56.9%), extremities (35.6%), and head and neck (7.4%). More patients in the 2-cm margin group required reconstruction (34.9 vs. 13.6%; p < 0.0001). There was an increased wound necrosis rate in the 2-cm arm (0.5 vs. 3.6%; p = 0.036). After 12 months' follow-up, no differences were noted in QoL between groups. This pilot study demonstrates the feasibility of a large international RCT to provide a definitive answer to the optimal excision margin for patients with intermediate- to high-risk primary cutaneous melanoma.

X Demographics

X Demographics

The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 73 100%

Demographic breakdown

Readers by professional status Count As %
Other 8 11%
Researcher 8 11%
Student > Master 6 8%
Student > Bachelor 5 7%
Student > Doctoral Student 4 5%
Other 9 12%
Unknown 33 45%
Readers by discipline Count As %
Medicine and Dentistry 20 27%
Nursing and Health Professions 5 7%
Agricultural and Biological Sciences 4 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Biochemistry, Genetics and Molecular Biology 1 1%
Other 2 3%
Unknown 40 55%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2018.
All research outputs
#3,645,062
of 23,085,832 outputs
Outputs from Annals of Surgical Oncology
#1,052
of 6,547 outputs
Outputs of similar age
#71,963
of 331,098 outputs
Outputs of similar age from Annals of Surgical Oncology
#45
of 123 outputs
Altmetric has tracked 23,085,832 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,547 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,098 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.