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Mouse strain and sex as determinants of immune response to trivalent influenza vaccine

Overview of attention for article published in Life Sciences, August 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

twitter
3 tweeters

Citations

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11 Dimensions

Readers on

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18 Mendeley
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Title
Mouse strain and sex as determinants of immune response to trivalent influenza vaccine
Published in
Life Sciences, August 2018
DOI 10.1016/j.lfs.2018.05.056
Pubmed ID
Authors

Raisa Petrović, Biljana Bufan, Nevena Arsenović-Ranin, Irena Živković, Rajna Minić, Katarina Radojević, Gordana Leposavić

Abstract

The study examined the influence of sex and mouse strain on germinal center (GC) reaction and antibody responses to seasonal split trivalent influenza vaccine (TIV). C57BL/6 and BALB/c mice of both sexes were immunized with TIV and examined for specific antibody response by ELISA. Splenic T follicular regulatory (Tfr), T follicular helper (Tfh) and GC B cells are detected by flow cytometry. The proliferative response of splenocytes, and concentrations of IFN-γ and IL-4 upon restimulation with vaccine antigens were examined by 7-AAD staining and ELISA, respectively. BALB/c mice developed more robust IgG responses to vaccine type A antigens than their sex-matched C57BL/6 counterparts, while that to B antigen did not differ between strains. In both strains IgG responses against type A vaccine antigens were greater in females than in males. The greater IgG responses correlated with lower splenic Tfr/Tfh and Tfr/GC B cell ratios and greater vaccine antigen-specific proliferative responses of CD4+ and B cells in splenocyte cultures. In both mouse strains IgG2a(c)/IgG1 ratios were comparable between sexes, but lower in BALB/c than in C57BL/6 mice indicating a shift in Th1/Th2 balance towards Th2 response in BALB/c ones. Consistently, splenocytes from BALB/c mice produced more IL-4 and less IFN-γ than those from C57BL/6 mice. The study indicated that magnitude of humoral response to influenza type A haemagglutinins depends on mouse strain and sex, and thereby set background for the vaccination strategies taking into account biological sex, and in a longterm perspective individual differences in immune reactivity.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 22%
Researcher 3 17%
Student > Bachelor 3 17%
Student > Master 2 11%
Student > Doctoral Student 1 6%
Other 3 17%
Unknown 2 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 22%
Immunology and Microbiology 4 22%
Medicine and Dentistry 2 11%
Mathematics 1 6%
Arts and Humanities 1 6%
Other 2 11%
Unknown 4 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2021.
All research outputs
#12,099,990
of 21,297,980 outputs
Outputs from Life Sciences
#4,084
of 6,766 outputs
Outputs of similar age
#139,829
of 299,237 outputs
Outputs of similar age from Life Sciences
#14
of 66 outputs
Altmetric has tracked 21,297,980 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,766 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,237 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.