Title |
Vascular endothelial growth factor and pulmonary hypertension in children with beta thalassemia major
|
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Published in |
Jornal de Pediatria, June 2018
|
DOI | 10.1016/j.jped.2018.05.003 |
Pubmed ID | |
Authors |
Usama M Alkholy, Soma Abdalla Mohamed, Marwa Elhady, Shahinaz El Attar, Nermin Abdalmonem, Ahmed Zaki |
Abstract |
The purpose of this study was to illustrate the association between vascular endothelial growth factor level and pulmonary artery hypertension in children with β-thalassemia major. This case-control study was conducted on 116 children with β-thalassemia major; 58 of them had pulmonary artery hypertension. They were compared to 58 healthy children who were age and sex-matched (control group). Serum levels of vascular endothelial growth factor and echocardiographic assessment were done for all children. Vascular endothelial growth factor serum level was significantly higher in children with β-thalassemia major with pulmonary artery hypertension than in those without pulmonary artery hypertension, as well as in control groups (p<0.001). Vascular endothelial growth factor serum level had a significant positive correlation with pulmonary artery pressure and serum ferritin, as well as a significant negative correlation with the duration of chelation therapy. Logistic regression analysis revealed that elevated vascular endothelial growth factor (OR=1.5; 95% CI, 1.137-2.065; p=0.005) was an independent risk factor of pulmonary artery hypertension in such children. Vascular endothelial growth factor serum level at a cutoff point of >169pg/mL had 93.1% sensitivity and 93.1% specificity for the presence of pulmonary artery hypertension in children with β-thalassemia major. Elevated vascular endothelial growth factor serum level is associated with pulmonary artery hypertension in children with β-thalassemia. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 4 | 16% |
Other | 3 | 12% |
Student > Master | 3 | 12% |
Lecturer | 1 | 4% |
Student > Ph. D. Student | 1 | 4% |
Other | 1 | 4% |
Unknown | 12 | 48% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 28% |
Nursing and Health Professions | 3 | 12% |
Social Sciences | 1 | 4% |
Unknown | 14 | 56% |