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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer
|
|---|---|
| Published in |
Nature Medicine, June 2018
|
| DOI | 10.1038/s41591-018-0040-8 |
| Pubmed ID | |
| Authors |
Nikolaos Zacharakis, Harshini Chinnasamy, Mary Black, Hui Xu, Yong-Chen Lu, Zhili Zheng, Anna Pasetto, Michelle Langhan, Thomas Shelton, Todd Prickett, Jared Gartner, Li Jia, Katarzyna Trebska-McGowan, Robert P. Somerville, Paul F. Robbins, Steven A. Rosenberg, Stephanie L. Goff, Steven A. Feldman |
| Abstract |
Immunotherapy using either checkpoint blockade or the adoptive transfer of antitumor lymphocytes has shown effectiveness in treating cancers with high levels of somatic mutations-such as melanoma, smoking-induced lung cancers and bladder cancer-with little effect in other common epithelial cancers that have lower mutation rates, such as those arising in the gastrointestinal tract, breast and ovary1-7. Adoptive transfer of autologous lymphocytes that specifically target proteins encoded by somatically mutated genes has mediated substantial objective clinical regressions in patients with metastatic bile duct, colon and cervical cancers8-11. We present a patient with chemorefractory hormone receptor (HR)-positive metastatic breast cancer who was treated with tumor-infiltrating lymphocytes (TILs) reactive against mutant versions of four proteins-SLC3A2, KIAA0368, CADPS2 and CTSB. Adoptive transfer of these mutant-protein-specific TILs in conjunction with interleukin (IL)-2 and checkpoint blockade mediated the complete durable regression of metastatic breast cancer, which is now ongoing for >22 months, and it represents a new immunotherapy approach for the treatment of these patients. |
X Demographics
The data shown below were collected from the profiles of 1,190 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 189 | 16% |
| Spain | 83 | 7% |
| United Kingdom | 55 | 5% |
| Japan | 33 | 3% |
| Thailand | 32 | 3% |
| France | 23 | 2% |
| Australia | 16 | 1% |
| India | 15 | 1% |
| Canada | 13 | 1% |
| Other | 147 | 12% |
| Unknown | 584 | 49% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 919 | 77% |
| Scientists | 195 | 16% |
| Practitioners (doctors, other healthcare professionals) | 60 | 5% |
| Science communicators (journalists, bloggers, editors) | 16 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,280 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1280 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 286 | 22% |
| Student > Ph. D. Student | 233 | 18% |
| Student > Master | 118 | 9% |
| Student > Bachelor | 92 | 7% |
| Other | 83 | 6% |
| Other | 194 | 15% |
| Unknown | 274 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 261 | 20% |
| Medicine and Dentistry | 188 | 15% |
| Immunology and Microbiology | 173 | 14% |
| Agricultural and Biological Sciences | 166 | 13% |
| Engineering | 30 | 2% |
| Other | 140 | 11% |
| Unknown | 322 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2166. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2024.
All research outputs
#4,081
of 25,807,758 outputs
Outputs from Nature Medicine
#72
of 9,437 outputs
Outputs of similar age
#55
of 344,104 outputs
Outputs of similar age from Nature Medicine
#1
of 115 outputs
Altmetric has tracked 25,807,758 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,437 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 105.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,104 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 115 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.