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The iBeetle large-scale RNAi screen reveals gene functions for insect development and physiology

Overview of attention for article published in Nature Communications, July 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

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3 news outlets
blogs
3 blogs
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22 X users

Citations

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141 Dimensions

Readers on

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161 Mendeley
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Title
The iBeetle large-scale RNAi screen reveals gene functions for insect development and physiology
Published in
Nature Communications, July 2015
DOI 10.1038/ncomms8822
Pubmed ID
Authors

Christian Schmitt-Engel, Dorothea Schultheis, Jonas Schwirz, Nadi Ströhlein, Nicole Troelenberg, Upalparna Majumdar, Van Anh Dao, Daniela Grossmann, Tobias Richter, Maike Tech, Jürgen Dönitz, Lizzy Gerischer, Mirko Theis, Inga Schild, Jochen Trauner, Nikolaus D. B. Koniszewski, Elke Küster, Sebastian Kittelmann, Yonggang Hu, Sabrina Lehmann, Janna Siemanowski, Julia Ulrich, Kristen A. Panfilio, Reinhard Schröder, Burkhard Morgenstern, Mario Stanke, Frank Buchhholz, Manfred Frasch, Siegfried Roth, Ernst A. Wimmer, Michael Schoppmeier, Martin Klingler, Gregor Bucher

Abstract

Genetic screens are powerful tools to identify the genes required for a given biological process. However, for technical reasons, comprehensive screens have been restricted to very few model organisms. Therefore, although deep sequencing is revealing the genes of ever more insect species, the functional studies predominantly focus on candidate genes previously identified in Drosophila, which is biasing research towards conserved gene functions. RNAi screens in other organisms promise to reduce this bias. Here we present the results of the iBeetle screen, a large-scale, unbiased RNAi screen in the red flour beetle, Tribolium castaneum, which identifies gene functions in embryonic and postembryonic development, physiology and cell biology. The utility of Tribolium as a screening platform is demonstrated by the identification of genes involved in insect epithelial adhesion. This work transcends the restrictions of the candidate gene approach and opens fields of research not accessible in Drosophila.

X Demographics

X Demographics

The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 161 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 1%
United States 1 <1%
Slovenia 1 <1%
Unknown 157 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 37 23%
Student > Ph. D. Student 29 18%
Student > Master 19 12%
Student > Bachelor 19 12%
Other 8 5%
Other 26 16%
Unknown 23 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 82 51%
Biochemistry, Genetics and Molecular Biology 38 24%
Engineering 2 1%
Computer Science 2 1%
Business, Management and Accounting 1 <1%
Other 6 4%
Unknown 30 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 51. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2019.
All research outputs
#782,416
of 24,552,012 outputs
Outputs from Nature Communications
#13,138
of 52,859 outputs
Outputs of similar age
#9,618
of 268,311 outputs
Outputs of similar age from Nature Communications
#160
of 799 outputs
Altmetric has tracked 24,552,012 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 52,859 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.1. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,311 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 799 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.