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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition
|
|---|---|
| Published in |
Nature Communications, July 2015
|
| DOI | 10.1038/ncomms8677 |
| Pubmed ID | |
| Authors |
Ronan Russell, Lukas Perkhofer, Stefan Liebau, Qiong Lin, André Lechel, Fenja M Feld, Elisabeth Hessmann, Jochen Gaedcke, Melanie Güthle, Martin Zenke, Daniel Hartmann, Guido von Figura, Stephanie E Weissinger, Karl-Lenhard Rudolph, Peter Möller, Jochen K Lennerz, Thomas Seufferlein, Martin Wagner, Alexander Kleger |
| Abstract |
Pancreatic ductal adenocarcinoma (PDAC) is associated with accumulation of particular oncogenic mutations and recent genetic sequencing studies have identified ataxia telangiectasia-mutated (ATM) mutations in PDAC cohorts. Here we report that conditional deletion of ATM in a mouse model of PDAC induces a greater number of proliferative precursor lesions coupled with a pronounced fibrotic reaction. ATM-targeted mice display altered TGFβ-superfamily signalling and enhanced epithelial-to-mesenchymal transition (EMT) coupled with shortened survival. Notably, our mouse model recapitulates many features of more aggressive human PDAC subtypes. Particularly, we report that low expression of ATM predicts EMT, a gene signature specific for Bmp4 signalling and poor prognosis in human PDAC. Our data suggest an intimate link between ATM expression and pancreatic cancer progression in mice and men. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| China | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 60% |
| Members of the public | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| France | 1 | <1% |
| Unknown | 124 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 20% |
| Researcher | 19 | 15% |
| Student > Master | 16 | 13% |
| Student > Bachelor | 13 | 10% |
| Other | 8 | 6% |
| Other | 16 | 13% |
| Unknown | 30 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 33 | 26% |
| Medicine and Dentistry | 23 | 18% |
| Agricultural and Biological Sciences | 19 | 15% |
| Immunology and Microbiology | 4 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 11 | 9% |
| Unknown | 35 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2016.
All research outputs
#1,543,763
of 25,928,676 outputs
Outputs from Nature Communications
#22,441
of 59,130 outputs
Outputs of similar age
#18,848
of 276,423 outputs
Outputs of similar age from Nature Communications
#260
of 800 outputs
Altmetric has tracked 25,928,676 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 59,130 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.4. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,423 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 800 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.