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Voltage-gated Sodium Channels: Structure, Function and Channelopathies

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Cover of 'Voltage-gated Sodium Channels: Structure, Function and Channelopathies'

Table of Contents

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    Book Overview
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    Chapter 43 Cardiac Arrhythmias Related to Sodium Channel Dysfunction
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    Chapter 44 Structural Models of Ligand-Bound Sodium Channels
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    Chapter 45 The Cardiac Sodium Channel and Its Protein Partners
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    Chapter 46 Effects of Benzothiazolamines on Voltage-Gated Sodium Channels
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    Chapter 47 Sodium Channel Trafficking
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    Chapter 48 Voltage-Gated Sodium Channel β Subunits and Their Related Diseases
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    Chapter 52 Sodium Channelopathies of Skeletal Muscle
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    Chapter 53 Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C
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    Chapter 54 Gating Pore Currents in Sodium Channels
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    Chapter 61 Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective
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    Chapter 63 Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells
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    Chapter 66 Toxins That Affect Voltage-Gated Sodium Channels
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    Chapter 69 Posttranslational Modification of Sodium Channels
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    Chapter 70 Evolutionary History of Voltage-Gated Sodium Channels
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    Chapter 73 Mechanisms of Drug Binding to Voltage-Gated Sodium Channels
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    Chapter 75 Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits
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    Chapter 91 Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain
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    Chapter 97 Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7
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    Chapter 99 pH Modulation of Voltage-Gated Sodium Channels
Attention for Chapter 66: Toxins That Affect Voltage-Gated Sodium Channels
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Chapter title
Toxins That Affect Voltage-Gated Sodium Channels
Chapter number 66
Book title
Voltage-gated Sodium Channels: Structure, Function and Channelopathies
Published in
Handbook of experimental pharmacology, January 2017
DOI 10.1007/164_2017_66
Pubmed ID
29071509
Book ISBNs
978-3-31-990283-8, 978-3-31-990284-5
Authors

Yonghua Ji, Ji, Yonghua

Abstract

Voltage-gated sodium channels (VGSCs) are critical in generation and conduction of electrical signals in multiple excitable tissues. Natural toxins, produced by animal, plant, and microorganisms, target VGSCs through diverse strategies developed over millions of years of evolutions. Studying of the diverse interaction between VGSC and VGSC-targeting toxins has been contributing to the increasing understanding of molecular structure and function, pharmacology, and drug development potential of VGSCs. This chapter aims to summarize some of the current views on the VGSC-toxin interaction based on the established receptor sites of VGSC for natural toxins.

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Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 33%
Student > Postgraduate 2 17%
Student > Ph. D. Student 2 17%
Researcher 2 17%
Unspecified 1 8%
Other 1 8%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 42%
Neuroscience 3 25%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Unspecified 1 8%
Medicine and Dentistry 1 8%
Other 1 8%

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