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Fratricide activity of MafB protein of N. meningitidis strain B16B6

Overview of attention for article published in BMC Microbiology, August 2015
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
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Mentioned by

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4 tweeters

Citations

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8 Dimensions

Readers on

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16 Mendeley
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Title
Fratricide activity of MafB protein of N. meningitidis strain B16B6
Published in
BMC Microbiology, August 2015
DOI 10.1186/s12866-015-0493-6
Pubmed ID
Authors

Jesús Arenas, Vincent de Maat, Laura Catón, Massis Krekorian, Juan Cruz Herrero, Flavio Ferrara, Jan Tommassen

Abstract

Neisseria meningitidis is an inhabitant of the mucosal surfaces of the human nasopharynx. We recently demonstrated that the secreted meningococcal Two-partner secretion protein A (TpsA) is involved in interbacterial competition. The C-terminal end of the large TpsA protein contains a small toxic domain that inhibits the growth of target bacteria. The producing cells are protected from this toxic activity by a small immunity protein that is encoded by the gene immediately downstream of the tpsA gene. Further downstream on the chromosome, a repertoire of toxic modules, designated tpsC cassettes, is encoded that could replace the toxic module of TpsA by recombination. Each tpsC cassette is associated with a gene encoding a cognate immunity protein. Blast searchers using the toxic domains of TpsA and TpsC proteins as queries identified homologies with the C-terminal part of neisserial MafB proteins, which, for the rest, showed no sequence similarity to TpsA proteins. On the chromosome, mafB genes are part of genomic islands, which include cassettes for additional toxic modules as well as genes putatively encoding immunity proteins. We demonstrate that a MafB protein of strain B16B6 inhibits the growth of a strain that does not produce the corresponding immunity protein. Assays in E. coli confirmed that the C-terminal region of MafB is responsible for toxicity, which is inhibited by the cognate immunity protein. Pull-down assays revealed direct interaction between MafB toxic domains and the cognate immunity proteins. The meningococcal MafB proteins are novel toxic proteins involved in interbacterial competition.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 38%
Student > Ph. D. Student 4 25%
Student > Bachelor 2 13%
Other 1 6%
Student > Postgraduate 1 6%
Other 0 0%
Unknown 2 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 31%
Immunology and Microbiology 5 31%
Agricultural and Biological Sciences 4 25%
Medicine and Dentistry 1 6%
Unknown 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2015.
All research outputs
#6,487,439
of 11,331,824 outputs
Outputs from BMC Microbiology
#750
of 1,598 outputs
Outputs of similar age
#105,826
of 235,854 outputs
Outputs of similar age from BMC Microbiology
#19
of 45 outputs
Altmetric has tracked 11,331,824 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,598 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,854 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.