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Hyperfiltration in Indigenous Australians with and without diabetes

Overview of attention for article published in Nephrology Dialysis Transplantation, July 2015
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Hyperfiltration in Indigenous Australians with and without diabetes
Published in
Nephrology Dialysis Transplantation, July 2015
DOI 10.1093/ndt/gfv230
Pubmed ID

Elif I. Ekinci, Jaquelyne T. Hughes, Mark D. Chatfield, Paul D. Lawton, Graham R. D. Jones, Andrew G. Ellis, Alan Cass, Mark Thomas, Richard J. MacIsaac, Kerin O'Dea, George Jerums, Louise J. Maple-Brown


Hyperfiltration (HF) has been linked to the development of diabetic kidney disease (DKD), but the causative or predictive role of HF in the pathogenesis of DKD still remains unclear. To date, there have been no studies of HF in Indigenous Australians, a population with high rates of both diabetes and end-stage kidney disease. We aimed to compare the characteristics and frequency of HF in Indigenous Australians with and without type 2 diabetes. Indigenous Australian participants, recruited across five pre-defined strata of health, diabetes status and kidney function, had a reference glomerular filtration rate (GFR) measured using plasma disappearance of iohexol [measured GFR(mGFR)] over 4 h. HF was defined in various ways: (i) mGFR > 144 mL/min/1.73 m(2), which is mGFR > 1.96 × SD above the mean of the mGFR in non-diabetic participants with normal albuminuria and normal renal function (mGFR > 90 mL/min/1.73 m(2)); (ii) age-corrected mGFR (>144 mL/min/1.73 m(2)) to account for the effect of ageing on GFR in subjects over 40 years of age with cut-off 1 mL/min/1.73 m(2) lower for every year; (iii) mGFR > 144 mL/min, without correction for body surface area or age, as well as (iv) mGFR > 125 mL/min/1.73 m(2), without adjustment for age. A total of 383 Indigenous participants, 125 with and 258 without diabetes, with mGFR > 90 mL/min/1.73 m(2) were studied. The proportion of participants with HF was 7% using mGFR > 144 mL/min/1.73 m(2), 11% using the age-adjusted definition, 19% using mGFR > 144 mL/min and 27% using mGFR > 125 mL/min/1.73 m(2). Diabetes was more common in participants with HF (40-74%) compared with normofiltering participants (28-31%), regardless of the definition of HF. HF exists in Indigenous Australians with and without diabetes. A greater proportion of participants had diabetes in HF group compared with normofiltration group. Long-term follow-up of this cohort is necessary to determine if HF plays a role in the development of DKD and non-DKD.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 20%
Student > Ph. D. Student 3 12%
Student > Bachelor 3 12%
Student > Master 2 8%
Student > Postgraduate 2 8%
Other 5 20%
Unknown 5 20%
Readers by discipline Count As %
Medicine and Dentistry 13 52%
Nursing and Health Professions 2 8%
Computer Science 1 4%
Psychology 1 4%
Physics and Astronomy 1 4%
Other 1 4%
Unknown 6 24%