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The Number of Patients and Events Required to Limit the Risk of Overestimation of Intervention Effects in Meta-Analysis—A Simulation Study

Overview of attention for article published in PLOS ONE, October 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

blogs
1 blog
twitter
7 X users

Citations

dimensions_citation
284 Dimensions

Readers on

mendeley
87 Mendeley
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Title
The Number of Patients and Events Required to Limit the Risk of Overestimation of Intervention Effects in Meta-Analysis—A Simulation Study
Published in
PLOS ONE, October 2011
DOI 10.1371/journal.pone.0025491
Pubmed ID
Authors

Kristian Thorlund, Georgina Imberger, Michael Walsh, Rong Chu, Christian Gluud, Jørn Wetterslev, Gordon Guyatt, Philip J. Devereaux, Lehana Thabane

Abstract

Meta-analyses including a limited number of patients and events are prone to yield overestimated intervention effect estimates. While many assume bias is the cause of overestimation, theoretical considerations suggest that random error may be an equal or more frequent cause. The independent impact of random error on meta-analyzed intervention effects has not previously been explored. It has been suggested that surpassing the optimal information size (i.e., the required meta-analysis sample size) provides sufficient protection against overestimation due to random error, but this claim has not yet been validated.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Netherlands 1 1%
France 1 1%
Peru 1 1%
Italy 1 1%
Spain 1 1%
Denmark 1 1%
Unknown 79 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 17%
Student > Ph. D. Student 14 16%
Student > Master 12 14%
Other 6 7%
Student > Postgraduate 6 7%
Other 18 21%
Unknown 16 18%
Readers by discipline Count As %
Medicine and Dentistry 38 44%
Agricultural and Biological Sciences 6 7%
Nursing and Health Professions 3 3%
Psychology 3 3%
Mathematics 3 3%
Other 10 11%
Unknown 24 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2021.
All research outputs
#2,698,928
of 23,577,761 outputs
Outputs from PLOS ONE
#33,858
of 202,084 outputs
Outputs of similar age
#14,379
of 140,838 outputs
Outputs of similar age from PLOS ONE
#369
of 2,569 outputs
Altmetric has tracked 23,577,761 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 202,084 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.3. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,838 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 2,569 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.