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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cerebral White Matter Lesions and Affective Episodes Correlate in Male Individuals with Bipolar Disorder
|
|---|---|
| Published in |
PLOS ONE, August 2015
|
| DOI | 10.1371/journal.pone.0135313 |
| Pubmed ID | |
| Authors |
Armin Birner, Stephan Seiler, Nina Lackner, Susanne A. Bengesser, Robert Queissner, Frederike T. Fellendorf, Martina Platzer, Stefan Ropele, Christian Enzinger, Petra Schwingenschuh, Harald Mangge, Lukas Pirpamer, Hannes Deutschmann, Roger S. McIntyre, Hans-Peter Kapfhammer, Bernd Reininghaus, Eva Z. Reininghaus |
| Abstract |
Cerebral white matter lesions (WML) have been found in normal aging, vascular disease and several neuropsychiatric conditions. Correlations of WML with clinical parameters in BD have been described, but not with the number of affective episodes, illness duration, age of onset and Body Mass Index in a well characterized group of euthymic bipolar adults. Herein, we aimed to evaluate the associations between bipolar course of illness parameters and WML measured with volumetric analysis. In a cross-sectional study 100 euthymic individuals with BD as well as 54 healthy controls (HC) were enrolled to undergo brain magnetic resonance imaging using 3T including a FLAIR sequence for volumetric assessment of WML-load using FSL-software. Additionally, clinical characteristics and psychometric measures including Structured Clinical Interview according to DSM-IV, Hamilton-Depression, Young Mania Rating Scale and Beck's Depression Inventory were evaluated. Individuals with BD had significantly more (F = 3.968, p < .05) WML (Mdn = 3710mm3; IQR = 2961mm3) than HC (Mdn = 2185mm3; IQR = 1665mm3). BD men (Mdn = 4095mm3; IQR = 3295mm3) and BD women (Mdn = 3032mm3; IQR = 2816mm3) did not significantly differ as to the WML-load or the number and type of risk factors for WML. However, in men only, the number of manic/hypomanic episodes (r = 0.72; p < .001) as well as depressive episodes (r = 0.51; p < .001) correlated positively with WML-load. WML-load strongly correlated with the number of manic episodes in male BD patients, suggesting that men might be more vulnerable to mania in the context of cerebral white matter changes. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 73 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 11% |
| Student > Master | 8 | 11% |
| Student > Bachelor | 7 | 10% |
| Other | 6 | 8% |
| Student > Doctoral Student | 5 | 7% |
| Other | 13 | 18% |
| Unknown | 26 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 27% |
| Neuroscience | 15 | 21% |
| Psychology | 5 | 7% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Nursing and Health Professions | 2 | 3% |
| Other | 4 | 5% |
| Unknown | 24 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2016.
All research outputs
#13,952,587
of 22,821,814 outputs
Outputs from PLOS ONE
#112,745
of 194,753 outputs
Outputs of similar age
#131,143
of 264,084 outputs
Outputs of similar age from PLOS ONE
#3,199
of 6,133 outputs
Altmetric has tracked 22,821,814 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,753 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,084 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6,133 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.