(2/10) Similar low-frequency activity was recently profiled in M1 & shown to be disrupted post-stroke and track recovery. Our work here may be an important precursor to check if similar activity in M1-CB networks might be a useful biomarker for recover
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Low-frequency oscillations (LFOs, 0.5-4Hz) were used as proxy for neural activity; indeed, we found that LFO amplitudes reliably peaked at specific phases of movement across the grasp n/w (example M1 channel here, see also: https://t.co/y0d2E5MrfK). (4/n)
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This finding likely has important implications for translation to stroke via restoration of LFO dynamics https://t.co/tDiV4wQrVf and https://t.co/TmwFRrHOJT (4/4)
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Previous work from our lab (https://t.co/TmwFRrHOJT) demonstrated that epidural stimulation boosts low freq oscillatory patterns to improve reaching and grasping. We wanted to see if a similar approach would work in NHPs. (2/12) https://t.co/fFPZ6VqVDG