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Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer

Overview of attention for article published in JAMA: Journal of the American Medical Association, June 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
52 news outlets
blogs
3 blogs
twitter
165 tweeters
facebook
4 Facebook pages
googleplus
3 Google+ users

Citations

dimensions_citation
50 Dimensions

Readers on

mendeley
99 Mendeley
citeulike
1 CiteULike
Title
Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer
Published in
JAMA: Journal of the American Medical Association, June 2018
DOI 10.1001/jama.2018.6228
Pubmed ID
Authors

Chunling Hu, Steven N. Hart, Eric C. Polley, Rohan Gnanaolivu, Hermela Shimelis, Kun Y. Lee, Jenna Lilyquist, Jie Na, Raymond Moore, Samuel O. Antwi, William R. Bamlet, Kari G. Chaffee, John DiCarlo, Zhong Wu, Raed Samara, Pashtoon M. Kasi, Robert R. McWilliams, Gloria M. Petersen, Fergus J. Couch

Abstract

Individuals genetically predisposed to pancreatic cancer may benefit from early detection. Genes that predispose to pancreatic cancer and the risks of pancreatic cancer associated with mutations in these genes are not well defined. To determine whether inherited germline mutations in cancer predisposition genes are associated with increased risks of pancreatic cancer. Case-control analysis to identify pancreatic cancer predisposition genes; longitudinal analysis of patients with pancreatic cancer for prognosis. The study included 3030 adults diagnosed as having pancreatic cancer and enrolled in a Mayo Clinic registry between October 12, 2000, and March 31, 2016, with last follow-up on June 22, 2017. Reference controls were 123 136 individuals with exome sequence data in the public Genome Aggregation Database and 53 105 in the Exome Aggregation Consortium database. Individuals were classified based on carrying a deleterious mutation in cancer predisposition genes and having a personal or family history of cancer. Germline mutations in coding regions of 21 cancer predisposition genes were identified by sequencing of products from a custom multiplex polymerase chain reaction-based panel; associations of genes with pancreatic cancer were assessed by comparing frequency of mutations in genes of pancreatic cancer patients with those of reference controls. Comparing 3030 case patients with pancreatic cancer (43.2% female; 95.6% non-Hispanic white; mean age at diagnosis, 65.3 [SD, 10.7] years) with reference controls, significant associations were observed between pancreatic cancer and mutations in CDKN2A (0.3% of cases and 0.02% of controls; odds ratio [OR], 12.33; 95% CI, 5.43-25.61); TP53 (0.2% of cases and 0.02% of controls; OR, 6.70; 95% CI, 2.52-14.95); MLH1 (0.13% of cases and 0.02% of controls; OR, 6.66; 95% CI, 1.94-17.53); BRCA2 (1.9% of cases and 0.3% of controls; OR, 6.20; 95% CI, 4.62-8.17); ATM (2.3% of cases and 0.37% of controls; OR, 5.71; 95% CI, 4.38-7.33); and BRCA1 (0.6% of cases and 0.2% of controls; OR, 2.58; 95% CI, 1.54-4.05). In this case-control study, mutations in 6 genes associated with pancreatic cancer were found in 5.5% of all pancreatic cancer patients, including 7.9% of patients with a family history of pancreatic cancer and 5.2% of patients without a family history of pancreatic cancer. Further research is needed for replication in other populations.

Twitter Demographics

The data shown below were collected from the profiles of 165 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 99 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 22%
Student > Master 14 14%
Unspecified 13 13%
Student > Ph. D. Student 11 11%
Professor 9 9%
Other 30 30%
Readers by discipline Count As %
Medicine and Dentistry 36 36%
Unspecified 21 21%
Biochemistry, Genetics and Molecular Biology 18 18%
Agricultural and Biological Sciences 15 15%
Chemistry 2 2%
Other 7 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 515. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2019.
All research outputs
#15,493
of 13,521,482 outputs
Outputs from JAMA: Journal of the American Medical Association
#441
of 25,785 outputs
Outputs of similar age
#812
of 268,404 outputs
Outputs of similar age from JAMA: Journal of the American Medical Association
#21
of 344 outputs
Altmetric has tracked 13,521,482 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 25,785 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 47.5. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,404 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 344 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.