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Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer

Overview of attention for article published in JAMA: Journal of the American Medical Association, June 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
54 news outlets
blogs
3 blogs
twitter
157 tweeters
facebook
4 Facebook pages
googleplus
3 Google+ users

Citations

dimensions_citation
91 Dimensions

Readers on

mendeley
155 Mendeley
citeulike
1 CiteULike
Title
Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer
Published in
JAMA: Journal of the American Medical Association, June 2018
DOI 10.1001/jama.2018.6228
Pubmed ID
Authors

Chunling Hu, Steven N. Hart, Eric C. Polley, Rohan Gnanaolivu, Hermela Shimelis, Kun Y. Lee, Jenna Lilyquist, Jie Na, Raymond Moore, Samuel O. Antwi, William R. Bamlet, Kari G. Chaffee, John DiCarlo, Zhong Wu, Raed Samara, Pashtoon M. Kasi, Robert R. McWilliams, Gloria M. Petersen, Fergus J. Couch

Abstract

Individuals genetically predisposed to pancreatic cancer may benefit from early detection. Genes that predispose to pancreatic cancer and the risks of pancreatic cancer associated with mutations in these genes are not well defined. To determine whether inherited germline mutations in cancer predisposition genes are associated with increased risks of pancreatic cancer. Case-control analysis to identify pancreatic cancer predisposition genes; longitudinal analysis of patients with pancreatic cancer for prognosis. The study included 3030 adults diagnosed as having pancreatic cancer and enrolled in a Mayo Clinic registry between October 12, 2000, and March 31, 2016, with last follow-up on June 22, 2017. Reference controls were 123 136 individuals with exome sequence data in the public Genome Aggregation Database and 53 105 in the Exome Aggregation Consortium database. Individuals were classified based on carrying a deleterious mutation in cancer predisposition genes and having a personal or family history of cancer. Germline mutations in coding regions of 21 cancer predisposition genes were identified by sequencing of products from a custom multiplex polymerase chain reaction-based panel; associations of genes with pancreatic cancer were assessed by comparing frequency of mutations in genes of pancreatic cancer patients with those of reference controls. Comparing 3030 case patients with pancreatic cancer (43.2% female; 95.6% non-Hispanic white; mean age at diagnosis, 65.3 [SD, 10.7] years) with reference controls, significant associations were observed between pancreatic cancer and mutations in CDKN2A (0.3% of cases and 0.02% of controls; odds ratio [OR], 12.33; 95% CI, 5.43-25.61); TP53 (0.2% of cases and 0.02% of controls; OR, 6.70; 95% CI, 2.52-14.95); MLH1 (0.13% of cases and 0.02% of controls; OR, 6.66; 95% CI, 1.94-17.53); BRCA2 (1.9% of cases and 0.3% of controls; OR, 6.20; 95% CI, 4.62-8.17); ATM (2.3% of cases and 0.37% of controls; OR, 5.71; 95% CI, 4.38-7.33); and BRCA1 (0.6% of cases and 0.2% of controls; OR, 2.58; 95% CI, 1.54-4.05). In this case-control study, mutations in 6 genes associated with pancreatic cancer were found in 5.5% of all pancreatic cancer patients, including 7.9% of patients with a family history of pancreatic cancer and 5.2% of patients without a family history of pancreatic cancer. Further research is needed for replication in other populations.

Twitter Demographics

The data shown below were collected from the profiles of 157 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 155 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 155 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 28 18%
Student > Master 24 15%
Student > Ph. D. Student 17 11%
Student > Bachelor 16 10%
Other 14 9%
Other 29 19%
Unknown 27 17%
Readers by discipline Count As %
Medicine and Dentistry 51 33%
Biochemistry, Genetics and Molecular Biology 28 18%
Agricultural and Biological Sciences 15 10%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Immunology and Microbiology 3 2%
Other 12 8%
Unknown 41 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 526. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2020.
All research outputs
#19,627
of 15,417,774 outputs
Outputs from JAMA: Journal of the American Medical Association
#556
of 27,700 outputs
Outputs of similar age
#817
of 276,802 outputs
Outputs of similar age from JAMA: Journal of the American Medical Association
#19
of 344 outputs
Altmetric has tracked 15,417,774 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 27,700 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.9. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,802 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 344 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.