Title |
Intricate Transcriptional Networks of Classical Brown and Beige Fat Cells
|
---|---|
Published in |
Frontiers in endocrinology, August 2015
|
DOI | 10.3389/fendo.2015.00124 |
Pubmed ID | |
Authors |
Jun Hong Park, Wonhee Hur, Sean Bong Lee |
Abstract |
Brown adipocytes are a specialized cell type that is critical for adaptive thermogenesis, energy homeostasis, and metabolism. In response to cold, both classical brown fat and the newly identified "beige" or "brite" cells are activated by β-adrenergic signaling and catabolize stored lipids and carbohydrates to produce heat via UCP1. Once thought to be non-existent in adults, recent studies have discovered active classical brown and beige fat cells in humans, thus reinvigorating interest in brown and beige adipocytes. This review will focus on the newly discovered transcription factors and microRNAs that specify and orchestrate the classical brown and beige fat cell development. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Switzerland | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 22% |
Student > Master | 7 | 15% |
Researcher | 6 | 13% |
Student > Bachelor | 4 | 9% |
Student > Doctoral Student | 3 | 7% |
Other | 8 | 17% |
Unknown | 8 | 17% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 17 | 37% |
Medicine and Dentistry | 7 | 15% |
Agricultural and Biological Sciences | 7 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Arts and Humanities | 1 | 2% |
Other | 1 | 2% |
Unknown | 12 | 26% |