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The octopus genome and the evolution of cephalopod neural and morphological novelties

Overview of attention for article published in Nature, August 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Readers on

mendeley
573 Mendeley
citeulike
7 CiteULike
Title
The octopus genome and the evolution of cephalopod neural and morphological novelties
Published in
Nature, August 2015
DOI 10.1038/nature14668
Pubmed ID
Authors

Caroline B. Albertin, Oleg Simakov, Therese Mitros, Z. Yan Wang, Judit R. Pungor, Eric Edsinger-Gonzales, Sydney Brenner, Clifton W. Ragsdale, Daniel S. Rokhsar, Albertin, Caroline B, Simakov, Oleg, Mitros, Therese, Wang, Z Yan, Pungor, Judit R, Edsinger-Gonzales, Eric, Brenner, Sydney, Ragsdale, Clifton W, Rokhsar, Daniel S

Abstract

Coleoid cephalopods (octopus, squid and cuttlefish) are active, resourceful predators with a rich behavioural repertoire. They have the largest nervous systems among the invertebrates and present other striking morphological innovations including camera-like eyes, prehensile arms, a highly derived early embryogenesis and a remarkably sophisticated adaptive colouration system. To investigate the molecular bases of cephalopod brain and body innovations, we sequenced the genome and multiple transcriptomes of the California two-spot octopus, Octopus bimaculoides. We found no evidence for hypothesized whole-genome duplications in the octopus lineage. The core developmental and neuronal gene repertoire of the octopus is broadly similar to that found across invertebrate bilaterians, except for massive expansions in two gene families previously thought to be uniquely enlarged in vertebrates: the protocadherins, which regulate neuronal development, and the C2H2 superfamily of zinc-finger transcription factors. Extensive messenger RNA editing generates transcript and protein diversity in genes involved in neural excitability, as previously described, as well as in genes participating in a broad range of other cellular functions. We identified hundreds of cephalopod-specific genes, many of which showed elevated expression levels in such specialized structures as the skin, the suckers and the nervous system. Finally, we found evidence for large-scale genomic rearrangements that are closely associated with transposable element expansions. Our analysis suggests that substantial expansion of a handful of gene families, along with extensive remodelling of genome linkage and repetitive content, played a critical role in the evolution of cephalopod morphological innovations, including their large and complex nervous systems.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 573 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 24 4%
Brazil 7 1%
United Kingdom 7 1%
France 4 <1%
Germany 3 <1%
Japan 3 <1%
Peru 2 <1%
Sweden 2 <1%
Canada 2 <1%
Other 16 3%
Unknown 503 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 169 29%
Researcher 131 23%
Student > Bachelor 79 14%
Student > Master 70 12%
Student > Doctoral Student 26 5%
Other 98 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 390 68%
Biochemistry, Genetics and Molecular Biology 89 16%
Unspecified 17 3%
Neuroscience 14 2%
Computer Science 9 2%
Other 54 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1066. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2017.
All research outputs
#1,742
of 8,648,177 outputs
Outputs from Nature
#377
of 48,832 outputs
Outputs of similar age
#48
of 230,541 outputs
Outputs of similar age from Nature
#19
of 874 outputs
Altmetric has tracked 8,648,177 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 48,832 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 76.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,541 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 874 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.