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Associations of serum calcium levels and dietary calcium intake with incident type 2 diabetes over 10 years: the Korean Genome and Epidemiology Study (KoGES)

Overview of attention for article published in Diabetology & Metabolic Syndrome, June 2018
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Title
Associations of serum calcium levels and dietary calcium intake with incident type 2 diabetes over 10 years: the Korean Genome and Epidemiology Study (KoGES)
Published in
Diabetology & Metabolic Syndrome, June 2018
DOI 10.1186/s13098-018-0349-y
Pubmed ID
Authors

Kyoung-Nam Kim, Se-Young Oh, Yun-Chul Hong

Abstract

Previous evidence regarding the associations between serum calcium concentrations, dietary calcium intake, and type 2 diabetes (T2D) is limited. We investigated the longitudinal associations of serum calcium levels and dietary calcium intake with T2D development. This study used data from the Ansung-Ansan cohort, a community-based, prospective cohort that was followed up for 10 years. Cox regression models adjusted for potential confounders were used to evaluate the associations of serum calcium levels (mean, 9.41 mg/dL) and dietary calcium intake (median, 389.59 mg/day) with T2D incidence. Association between dietary calcium intake and serum calcium levels was assessed using linear regression models. Albumin-adjusted serum calcium levels were not associated with T2D risk (hazard ratio [HR] = 1.07, 95% confidence interval [CI] 0.96, 1.19, p-value = 0.2333). A one-unit increase in log-transformed, energy-adjusted dietary calcium intake was associated with a decreased risk of T2D (HR = 0.88, 95% CI 0.77, 1.00, p-value = 0.0460) and lower albumin-adjusted serum calcium levels (β = - 0.04, 95% CI - 0.07, - 0.02, p-value = 0.0014). The associations did not differ according to sex (all p-values for interaction > 0.10). Serum calcium levels were not associated with T2D risk, while higher dietary calcium intake was associated with a decreased risk of T2D development. These results have public health implications for predicting and preventing T2D development, as well as providing guidelines for diet and calcium supplementation.

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Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 13%
Student > Master 5 13%
Student > Ph. D. Student 4 11%
Researcher 3 8%
Other 2 5%
Other 4 11%
Unknown 15 39%
Readers by discipline Count As %
Medicine and Dentistry 7 18%
Biochemistry, Genetics and Molecular Biology 6 16%
Nursing and Health Professions 5 13%
Unspecified 1 3%
Computer Science 1 3%
Other 3 8%
Unknown 15 39%