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Mendeley readers
Attention Score in Context
| Title |
Ankyrin-B Syndrome: Enhanced Cardiac Function Balanced by Risk of Cardiac Death and Premature Senescence
|
|---|---|
| Published in |
PLOS ONE, October 2007
|
| DOI | 10.1371/journal.pone.0001051 |
| Pubmed ID | |
| Authors |
Peter J. Mohler, Jane A. Healy, Hui Xue, Annibale A. Puca, Crystal F. Kline, R. Rand Allingham, Evangelia G. Kranias, Howard A. Rockman, Vann Bennett |
| Abstract |
Here we report the unexpected finding that specific human ANK2 variants represent a new example of balanced human variants. The prevalence of certain ANK2 (encodes ankyrin-B) variants range from 2 percent of European individuals to 8 percent in individuals from West Africa. Ankyrin-B variants associated with severe human arrhythmia phenotypes (eg E1425G, V1516D, R1788W) were rare in the general population. Variants associated with less severe clinical and in vitro phenotypes were unexpectedly common. Studies with the ankyrin-B(+/-) mouse reveal both benefits of enhanced cardiac contractility, as well as costs in earlier senescence and reduced lifespan. Together these findings suggest a constellation of traits that we term "ankyrin-B syndrome", which may contribute to both aging-related disorders and enhanced cardiac function. |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 3% |
| Switzerland | 1 | 3% |
| Unknown | 29 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor > Associate Professor | 6 | 19% |
| Professor | 5 | 16% |
| Student > Ph. D. Student | 4 | 13% |
| Student > Postgraduate | 3 | 10% |
| Researcher | 3 | 10% |
| Other | 7 | 23% |
| Unknown | 3 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 35% |
| Medicine and Dentistry | 7 | 23% |
| Biochemistry, Genetics and Molecular Biology | 5 | 16% |
| Neuroscience | 2 | 6% |
| Computer Science | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 4 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2015.
All research outputs
#7,464,917
of 22,821,814 outputs
Outputs from PLOS ONE
#88,950
of 194,753 outputs
Outputs of similar age
#25,445
of 75,599 outputs
Outputs of similar age from PLOS ONE
#133
of 229 outputs
Altmetric has tracked 22,821,814 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,753 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 75,599 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 229 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.