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Vaccination of Lactating Dairy Cows for the Prevention of Aflatoxin B1 Carry Over in Milk

Overview of attention for article published in PLOS ONE, October 2011
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Title
Vaccination of Lactating Dairy Cows for the Prevention of Aflatoxin B1 Carry Over in Milk
Published in
PLOS ONE, October 2011
DOI 10.1371/journal.pone.0026777
Pubmed ID
Authors

Luciano Polonelli, Laura Giovati, Walter Magliani, Stefania Conti, Stefano Sforza, Alessandro Calabretta, Claudio Casoli, Paola Ronzi, Ester Grilli, Antonio Gallo, Francesco Masoero, Gianfranco Piva

Abstract

The potential of anaflatoxin B(1) (AnAFB(1)) conjugated to keyhole limpet hemocyanin (KLH) as a vaccine (AnAFB(1)-KLH) in controlling the carry over of the aflatoxin B(1) (AFB(1)) metabolite aflatoxin M(1) (AFM(1)) in cow milk is reported. AFB(1) is the most carcinogenic compound in food and foodstuffs amongst aflatoxins (AFs). AnAFB(1) is AFB(1) chemically modified as AFB(1)-1(O-carboxymethyl) oxime. In comparison to AFB(1), AnAFB(1) has proven to be non-toxic in vitro to human hepatocarcinoma cells and non mutagenic to Salmonella typhimurium strains. AnAFB(1)-KLH was used for immunization of cows proving to induce a long lasting titer of anti-AFB(1) IgG antibodies (Abs) which were cross reactive with AFB(1), AFG(1), and AFG(2). The elicited anti-AFB(1) Abs were able to hinder the secretion of AFM(1) into the milk of cows continuously fed with AFB(1). Vaccination of lactating animals with conjugated AnAFB(1) may represent a solution to the public hazard constituted by milk and cheese contaminated with AFs.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Kenya 1 2%
Italy 1 2%
Unknown 60 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 29%
Student > Ph. D. Student 9 15%
Other 7 11%
Professor > Associate Professor 4 6%
Student > Master 4 6%
Other 12 19%
Unknown 8 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 32%
Medicine and Dentistry 7 11%
Chemistry 7 11%
Veterinary Science and Veterinary Medicine 4 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 12 19%
Unknown 10 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2011.
All research outputs
#15,238,442
of 22,656,971 outputs
Outputs from PLOS ONE
#129,737
of 193,432 outputs
Outputs of similar age
#95,964
of 140,785 outputs
Outputs of similar age from PLOS ONE
#1,685
of 2,608 outputs
Altmetric has tracked 22,656,971 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,432 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,785 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2,608 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.