Title |
Developmental Origins of Health and Disease: Integrating Environmental Influences
|
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Published in |
Molecular Endocrinology, July 2015
|
DOI | 10.1210/en.2015-1394 |
Pubmed ID | |
Authors |
Jerrold J Heindel, John Balbus, Linda Birnbaum, Marie Noel Brune-Drisse, Philippe Grandjean, Kimberly Gray, Philip J Landrigan, Peter D Sly, William Suk, Deborah Cory Slechta, Claudia Thompson, Mark Hanson |
Abstract |
There are now robust data supporting the Developmental Origins of Health and Disease (DOHaD) paradigm. This includes human and animal data focusing on nutrition or environmental chemicals during development. However, the term DOHaD has not been generally accepted as the official term to be used when one is concerned with understanding the pathophysiological basis for how environmental influences acting during early development influence the risk of later noncommunicable diseases. Similarly, there is no global research or public health program built around the DOHaD paradigm that encompasses all aspects of environment. To better inform the global health efforts aimed at addressing the growing epidemic of chronic noncommunicable diseases of environmental origin, we propose a two-pronged approach: first, to make it clear that the current concept of DOHaD comprehensively includes a range of environmental factors and their relevance to disease occurrence not just throughout the life span but potentially across several generations; and second, to initiate the discussion of how adoption of DOHaD can promote a more realistic, accurate, and integrative approach to understanding environmental disruption of developmental programming and better inform clinical and policy interventions. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 17% |
Canada | 2 | 17% |
Japan | 1 | 8% |
United Kingdom | 1 | 8% |
South Africa | 1 | 8% |
Unknown | 5 | 42% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 83% |
Practitioners (doctors, other healthcare professionals) | 2 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 2 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 374 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 67 | 18% |
Researcher | 51 | 13% |
Student > Master | 44 | 12% |
Student > Bachelor | 37 | 10% |
Other | 23 | 6% |
Other | 79 | 21% |
Unknown | 78 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 66 | 17% |
Agricultural and Biological Sciences | 47 | 12% |
Environmental Science | 29 | 8% |
Biochemistry, Genetics and Molecular Biology | 26 | 7% |
Social Sciences | 17 | 4% |
Other | 86 | 23% |
Unknown | 108 | 28% |