↓ Skip to main content

Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure

Overview of attention for article published in BMC Cardiovascular Disorders, August 2015
Altmetric Badge

Citations

dimensions_citation
11 Dimensions

Readers on

mendeley
38 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure
Published in
BMC Cardiovascular Disorders, August 2015
DOI 10.1186/s12872-015-0063-8
Pubmed ID
Authors

F Gaborit, H Bosselmann, N Tønder, K Iversen, T Kümler, C Kistorp, G Sölétormos, J P. Goetze, M Schou

Abstract

Both impaired left ventricular (LV) global longitudinal strain (GLS) and increased plasma concentrations of natriuretic peptides(NP) are associated with a poor outcome in heart failure (HF). Increased levels of NP reflect increased wall stress of the LV. However, little is known about the relationship between LV GLS and NP. This aim of this study was to evaluate the relationship between the echocardiographic measure LV GLS and plasma levels of NP. We prospectively included 149 patients with verified systolic HF at the baseline visit in an outpatient HF clinic. LV GLS was assessed by two dimension speckle tracking and plasma concentrations of N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) and pro-atrial-natriuretic-peptide (proANP) were analysed. The patients had a median age of 70 years, 28.2 % were females, 26.5 % were in functional class III-IV, median left ventricular ejection fraction (LVEF) was 33 % and median LV GLS was -11 %. LV GLS was associated with increased plasma concentrations of NT-proBNP and proANP in multivariate logistic regression (NT-proBNP: Odds RatioGLS: 7.25, 95 %-CI: 2.48-21.1, P < 0.001 and proANP: Odds RatioGLS: 3.26, 95-%-CI: 1.28-8.30, P = 0.013) and linear regression (NT-proBNP: βGLS: 1.19, 95 %-CI: 0.62-1.76, P < 0.001 and proANP: βGLS: 0.42, 95-%-CI: 0.11-0.72, P = 0.007) models after adjustment for traditional confounders (age, gender, body-mass-index, atrial fibrillation, renal function) and left atrial volume index. Impaired LV GLS is associated with increased plasma concentrations of NP and our data suggest that left ventricular myocardial mechanics estimated by LV GLS reflects myocardial wall stress in chronic systolic HF.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 3%
Unknown 37 97%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 5 13%
Other 4 11%
Student > Doctoral Student 4 11%
Student > Ph. D. Student 4 11%
Student > Bachelor 3 8%
Other 4 11%
Unknown 14 37%
Readers by discipline Count As %
Medicine and Dentistry 19 50%
Engineering 2 5%
Chemistry 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Unknown 15 39%