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The placenta: phenotypic and epigenetic modifications induced by Assisted Reproductive Technologies throughout pregnancy

Overview of attention for article published in Clinical Epigenetics, August 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)

Mentioned by

5 tweeters


39 Dimensions

Readers on

68 Mendeley
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The placenta: phenotypic and epigenetic modifications induced by Assisted Reproductive Technologies throughout pregnancy
Published in
Clinical Epigenetics, August 2015
DOI 10.1186/s13148-015-0120-2
Pubmed ID

Cécile Choux, Virginie Carmignac, Céline Bruno, Paul Sagot, Daniel Vaiman, Patricia Fauque


Today, there is growing interest in the potential epigenetic risk related to assisted reproductive technologies (ART). Much evidence in the literature supports the hypothesis that adverse pregnancy outcomes linked to ART are associated with abnormal trophoblastic invasion. The aim of this review is to investigate the relationship between epigenetic dysregulation caused by ART and subsequent placental response. The dialogue between the endometrium and the embryo is a crucial step to achieve successful trophoblastic invasion, thus ensuring a non-complicated pregnancy and healthy offspring. However, as described in this review, ART could impair both actors involved in this dialogue. First, ART may induce epigenetic defects in the conceptus by modifying the embryo environment. Second, as a result of hormone treatments, ART may impair endometrial receptivity. In some cases, it results in embryonic growth arrest but, when the development of the embryo continues, the placenta could bring adaptive responses throughout pregnancy. Amongst the different mechanisms, epigenetics, especially thanks to a finely tuned network of imprinted genes stimulated by foetal signals, may modify nutrient transfer, placental growth and vascularization. If these coping mechanisms are overwhelmed, improper maternal-foetal exchanges occur, potentially leading to adverse pregnancy outcomes such as abortion, preeclampsia or intra-uterine growth restriction. But in most cases, successful placental adaptation enables normal progress of the pregnancy. Nevertheless, the risks induced by these modifications during pregnancy are not fully understood. Metabolic diseases later in life could be exacerbated through the memory of epigenetic adaptation mechanisms established during pregnancy. Thus, more research is still needed to better understand abnormal interactions between the embryo and the milieu in artificial conditions. As trophectoderm cells are in direct contact with the environment, they deserve to be studied in more detail. The ultimate goal of these studies will be to render ART protocols safer. Optimization of the environment will be the key to improving the dialogue between the endometrium and embryo, so as to ensure that placentation after ART is similar to that following natural conception.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Poland 1 1%
France 1 1%
Switzerland 1 1%
Unknown 64 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 26%
Student > Ph. D. Student 12 18%
Student > Bachelor 10 15%
Student > Master 5 7%
Student > Postgraduate 5 7%
Other 10 15%
Unknown 8 12%
Readers by discipline Count As %
Medicine and Dentistry 20 29%
Agricultural and Biological Sciences 14 21%
Biochemistry, Genetics and Molecular Biology 11 16%
Nursing and Health Professions 5 7%
Veterinary Science and Veterinary Medicine 3 4%
Other 5 7%
Unknown 10 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2015.
All research outputs
of 14,210,914 outputs
Outputs from Clinical Epigenetics
of 744 outputs
Outputs of similar age
of 239,060 outputs
Outputs of similar age from Clinical Epigenetics
of 10 outputs
Altmetric has tracked 14,210,914 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 744 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,060 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one.