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The placenta: phenotypic and epigenetic modifications induced by Assisted Reproductive Technologies throughout pregnancy

Overview of attention for article published in Clinical Epigenetics, August 2015
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5 tweeters

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Title
The placenta: phenotypic and epigenetic modifications induced by Assisted Reproductive Technologies throughout pregnancy
Published in
Clinical Epigenetics, August 2015
DOI 10.1186/s13148-015-0120-2
Pubmed ID
Authors

Cécile Choux, Virginie Carmignac, Céline Bruno, Paul Sagot, Daniel Vaiman, Patricia Fauque

Abstract

Today, there is growing interest in the potential epigenetic risk related to assisted reproductive technologies (ART). Much evidence in the literature supports the hypothesis that adverse pregnancy outcomes linked to ART are associated with abnormal trophoblastic invasion. The aim of this review is to investigate the relationship between epigenetic dysregulation caused by ART and subsequent placental response. The dialogue between the endometrium and the embryo is a crucial step to achieve successful trophoblastic invasion, thus ensuring a non-complicated pregnancy and healthy offspring. However, as described in this review, ART could impair both actors involved in this dialogue. First, ART may induce epigenetic defects in the conceptus by modifying the embryo environment. Second, as a result of hormone treatments, ART may impair endometrial receptivity. In some cases, it results in embryonic growth arrest but, when the development of the embryo continues, the placenta could bring adaptive responses throughout pregnancy. Amongst the different mechanisms, epigenetics, especially thanks to a finely tuned network of imprinted genes stimulated by foetal signals, may modify nutrient transfer, placental growth and vascularization. If these coping mechanisms are overwhelmed, improper maternal-foetal exchanges occur, potentially leading to adverse pregnancy outcomes such as abortion, preeclampsia or intra-uterine growth restriction. But in most cases, successful placental adaptation enables normal progress of the pregnancy. Nevertheless, the risks induced by these modifications during pregnancy are not fully understood. Metabolic diseases later in life could be exacerbated through the memory of epigenetic adaptation mechanisms established during pregnancy. Thus, more research is still needed to better understand abnormal interactions between the embryo and the milieu in artificial conditions. As trophectoderm cells are in direct contact with the environment, they deserve to be studied in more detail. The ultimate goal of these studies will be to render ART protocols safer. Optimization of the environment will be the key to improving the dialogue between the endometrium and embryo, so as to ensure that placentation after ART is similar to that following natural conception.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Poland 1 2%
France 1 2%
Switzerland 1 2%
Unknown 57 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 26%
Student > Ph. D. Student 10 16%
Student > Bachelor 9 15%
Student > Master 6 10%
Student > Postgraduate 4 7%
Other 9 15%
Unknown 7 11%
Readers by discipline Count As %
Medicine and Dentistry 19 31%
Agricultural and Biological Sciences 13 21%
Biochemistry, Genetics and Molecular Biology 10 16%
Veterinary Science and Veterinary Medicine 3 5%
Nursing and Health Professions 3 5%
Other 5 8%
Unknown 8 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2015.
All research outputs
#4,091,376
of 4,794,677 outputs
Outputs from Clinical Epigenetics
#247
of 294 outputs
Outputs of similar age
#138,425
of 164,532 outputs
Outputs of similar age from Clinical Epigenetics
#37
of 44 outputs
Altmetric has tracked 4,794,677 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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