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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis
|
|---|---|
| Published in |
Journal of Neuroinflammation, November 2011
|
| DOI | 10.1186/1742-2094-8-150 |
| Pubmed ID | |
| Authors |
Jie Zhao, Tracy O'Connor, Robert Vassar |
| Abstract |
β-Amyloid (Aβ) plays a central role in Alzheimer's disease (AD) pathogenesis. Neurons are major sources of Aβ in the brain. However, astrocytes outnumber neurons by at least five-fold. Thus, even a small level of astrocytic Aβ production could make a significant contribution to Aβ burden in AD. Moreover, activated astrocytes may increase Aβ generation. β-Site APP cleaving enzyme 1 (BACE1) cleavage of amyloid precursor protein (APP) initiates Aβ production. Here, we explored whether pro-inflammatory cytokines or Aβ42 would increase astrocytic levels of BACE1, APP, and β-secretase processing, implying a feed-forward mechanism of astrocytic Aβ production. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 43% |
| France | 1 | 14% |
| Canada | 1 | 14% |
| Unknown | 2 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 307 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 3 | <1% |
| Germany | 2 | <1% |
| United States | 2 | <1% |
| Canada | 1 | <1% |
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 296 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 54 | 18% |
| Student > Ph. D. Student | 52 | 17% |
| Student > Bachelor | 51 | 17% |
| Researcher | 47 | 15% |
| Student > Doctoral Student | 15 | 5% |
| Other | 31 | 10% |
| Unknown | 57 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 80 | 26% |
| Neuroscience | 68 | 22% |
| Biochemistry, Genetics and Molecular Biology | 43 | 14% |
| Medicine and Dentistry | 19 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 3% |
| Other | 20 | 7% |
| Unknown | 69 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2024.
All research outputs
#7,241,396
of 25,374,374 outputs
Outputs from Journal of Neuroinflammation
#1,263
of 2,941 outputs
Outputs of similar age
#41,896
of 147,784 outputs
Outputs of similar age from Journal of Neuroinflammation
#4
of 21 outputs
Altmetric has tracked 25,374,374 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 2,941 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 147,784 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.