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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Translating nucleic acid-sensing pathways into therapies
|
|---|---|
| Published in |
Nature Reviews Immunology, August 2015
|
| DOI | 10.1038/nri3875 |
| Pubmed ID | |
| Authors |
Tobias Junt, Winfried Barchet |
| Abstract |
Nucleic acid sensing by innate receptors initiates immune defences against viruses and other pathogens. A hallmark of this response is the release of interferons (IFNs), which promote protective immunity by inducing IFN-stimulated genes (ISGs). A similar ISG signature is found in autoinflammatory and autoimmune conditions, indicating that chronic activation of nucleic acid-sensing pathways may contribute to these diseases. Here, we review how nucleic acid-sensing pathways are currently being targeted pharmacologically with both agonists and antagonists. We discuss how an improved understanding of the biology of these pathways is leading to novel therapies for infections, cancer, and autoimmune and autoinflammatory disorders, and how new therapeutics will, in turn, generate a deeper understanding of these complex diseases. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 29% |
| Brazil | 1 | 14% |
| Ecuador | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 280 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | <1% |
| United States | 2 | <1% |
| Norway | 1 | <1% |
| Germany | 1 | <1% |
| Mexico | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 272 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 73 | 26% |
| Student > Ph. D. Student | 55 | 20% |
| Student > Doctoral Student | 23 | 8% |
| Student > Bachelor | 20 | 7% |
| Student > Master | 19 | 7% |
| Other | 40 | 14% |
| Unknown | 50 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 77 | 28% |
| Medicine and Dentistry | 42 | 15% |
| Biochemistry, Genetics and Molecular Biology | 39 | 14% |
| Immunology and Microbiology | 33 | 12% |
| Chemistry | 11 | 4% |
| Other | 20 | 7% |
| Unknown | 58 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2023.
All research outputs
#1,732,153
of 24,257,963 outputs
Outputs from Nature Reviews Immunology
#715
of 2,584 outputs
Outputs of similar age
#23,253
of 270,692 outputs
Outputs of similar age from Nature Reviews Immunology
#5
of 33 outputs
Altmetric has tracked 24,257,963 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,584 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 42.1. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,692 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.