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Translating nucleic acid-sensing pathways into therapies

Overview of attention for article published in Nature Reviews Immunology, August 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

news
1 news outlet
twitter
8 tweeters
facebook
5 Facebook pages

Citations

dimensions_citation
65 Dimensions

Readers on

mendeley
190 Mendeley
citeulike
1 CiteULike
Title
Translating nucleic acid-sensing pathways into therapies
Published in
Nature Reviews Immunology, August 2015
DOI 10.1038/nri3875
Pubmed ID
Authors

Tobias Junt, Winfried Barchet

Abstract

Nucleic acid sensing by innate receptors initiates immune defences against viruses and other pathogens. A hallmark of this response is the release of interferons (IFNs), which promote protective immunity by inducing IFN-stimulated genes (ISGs). A similar ISG signature is found in autoinflammatory and autoimmune conditions, indicating that chronic activation of nucleic acid-sensing pathways may contribute to these diseases. Here, we review how nucleic acid-sensing pathways are currently being targeted pharmacologically with both agonists and antagonists. We discuss how an improved understanding of the biology of these pathways is leading to novel therapies for infections, cancer, and autoimmune and autoinflammatory disorders, and how new therapeutics will, in turn, generate a deeper understanding of these complex diseases.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 190 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Canada 2 1%
Japan 1 <1%
Mexico 1 <1%
Norway 1 <1%
Switzerland 1 <1%
Czechia 1 <1%
Germany 1 <1%
Unknown 179 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 55 29%
Student > Ph. D. Student 47 25%
Student > Doctoral Student 17 9%
Unspecified 16 8%
Student > Master 15 8%
Other 40 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 64 34%
Medicine and Dentistry 36 19%
Biochemistry, Genetics and Molecular Biology 27 14%
Unspecified 22 12%
Immunology and Microbiology 18 9%
Other 23 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2016.
All research outputs
#910,554
of 12,346,667 outputs
Outputs from Nature Reviews Immunology
#321
of 1,718 outputs
Outputs of similar age
#25,252
of 245,005 outputs
Outputs of similar age from Nature Reviews Immunology
#9
of 33 outputs
Altmetric has tracked 12,346,667 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,718 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 245,005 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.