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Inhibition of Histone Deacetylases 1 and 6 Enhances Cytarabine-Induced Apoptosis in Pediatric Acute Myeloid Leukemia Cells

Overview of attention for article published in PLOS ONE, February 2011
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Title
Inhibition of Histone Deacetylases 1 and 6 Enhances Cytarabine-Induced Apoptosis in Pediatric Acute Myeloid Leukemia Cells
Published in
PLOS ONE, February 2011
DOI 10.1371/journal.pone.0017138
Pubmed ID
Authors

Xuelian Xu, Chengzhi Xie, Holly Edwards, Hui Zhou, Steven A. Buck, Yubin Ge

Abstract

Pediatric acute myeloid leukemia (AML) remains a challenging disease to treat even with intensified cytarabine-based chemotherapy. Histone deacetylases (HDACs) have been reported to be promising therapeutic targets for treating AML. However, HDAC family members that are involved in chemotherapy sensitivities remain unknown. In this study, we sought to identify members of the HDAC family that are involved in cytarabine sensitivities, and to select the optimal HDACI that is most efficacious when combined with cytarabine for treating children with AML.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
United Kingdom 1 2%
Unknown 41 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 21%
Student > Ph. D. Student 9 21%
Student > Bachelor 7 16%
Student > Master 7 16%
Student > Doctoral Student 4 9%
Other 4 9%
Unknown 3 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 33%
Biochemistry, Genetics and Molecular Biology 7 16%
Medicine and Dentistry 5 12%
Chemistry 4 9%
Design 4 9%
Other 6 14%
Unknown 3 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2011.
All research outputs
#20,150,151
of 22,656,971 outputs
Outputs from PLOS ONE
#172,590
of 193,432 outputs
Outputs of similar age
#99,469
of 105,834 outputs
Outputs of similar age from PLOS ONE
#1,206
of 1,284 outputs
Altmetric has tracked 22,656,971 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,432 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 105,834 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,284 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.