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Mendeley readers
Attention Score in Context
| Title |
The FSHD Atrophic Myotube Phenotype Is Caused by DUX4 Expression
|
|---|---|
| Published in |
PLOS ONE, October 2011
|
| DOI | 10.1371/journal.pone.0026820 |
| Pubmed ID | |
| Authors |
Céline Vanderplanck, Eugénie Ansseau, Sébastien Charron, Nadia Stricwant, Alexandra Tassin, Dalila Laoudj-Chenivesse, Steve D. Wilton, Frédérique Coppée, Alexandra Belayew |
| Abstract |
Facioscapulohumeral muscular dystrophy (FSHD) is linked to deletions in 4q35 within the D4Z4 repeat array in which we identified the double homeobox 4 (DUX4) gene. We found stable DUX4 mRNAs only derived from the most distal D4Z4 unit and unexpectedly extended to the flanking pLAM region that provided an intron and a polyadenylation signal. DUX4 encodes a transcription factor expressed in FSHD but not control primary myoblasts or muscle biopsies. The DUX4 protein initiates a large transcription deregulation cascade leading to muscle atrophy and oxidative stress, which are FSHD key features. |
Mendeley readers
The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 130 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 37 | 28% |
| Student > Ph. D. Student | 23 | 17% |
| Student > Bachelor | 17 | 13% |
| Student > Master | 11 | 8% |
| Professor | 7 | 5% |
| Other | 14 | 11% |
| Unknown | 23 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 40 | 30% |
| Agricultural and Biological Sciences | 34 | 26% |
| Medicine and Dentistry | 17 | 13% |
| Chemistry | 4 | 3% |
| Neuroscience | 4 | 3% |
| Other | 8 | 6% |
| Unknown | 25 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2024.
All research outputs
#2,682,496
of 24,532,617 outputs
Outputs from PLOS ONE
#33,481
of 211,926 outputs
Outputs of similar age
#13,931
of 144,641 outputs
Outputs of similar age from PLOS ONE
#365
of 2,631 outputs
Altmetric has tracked 24,532,617 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 211,926 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 144,641 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 2,631 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.