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Serum hepcidin levels, iron status, and HFE gene alterations during the first year of life in healthy Spanish infants

Overview of attention for article published in Annals of Hematology, February 2018
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Title
Serum hepcidin levels, iron status, and HFE gene alterations during the first year of life in healthy Spanish infants
Published in
Annals of Hematology, February 2018
DOI 10.1007/s00277-018-3256-2
Pubmed ID
Authors

Nuria Aranda, Cristina Bedmar, Victoria Arija, Cristina Jardí, Rosa Jimenez-Feijoo, Natalia Ferré, Monica Tous

Abstract

The aims of this study were to describe hepcidin levels and to assess their associations with iron status and the main variants in the HFE gene in healthy and full-term newborns during the first year of life, as a longitudinal study conducted on 140 infants. Anthropometric and biochemical parameters, hepcidin, hemoglobin (Hb), serum ferritin (SF), transferrin saturation (TS), mean corpuscular volume (MCV), and C-reactive protein (CRP), were assessed in 6- and 12-month-olds. Infants were genotyped for the three main HFE variants: C282Y, H63D, and S65C. Hepcidin levels increased from 6 to 12 months of age (43.7 ± 1.5 to 52.0 ± 1.5 ng/mL; p < 0.001), showing higher levels in infants with better iron status compared to those with iron deficiency (ID) (44.8 ± 1.5 vs 37.9 ± 1.3 ng/mL, p < 0.018, and 54.3 ± 1.5 vs 44.0 ± 1.4 ng/mL, p < 0.038, in 6- and 12-month-olds, respectively). In multivariate linear regression models, iron status was found to be associated with hepcidin levels in infants with wild-type HFE gene (p = 0.046 and p = 0.048 in 6- and 12-month-olds, respectively). However, this association was not found in HFE-alteration-carrying infants. Hepcidin levels increased in healthy infants during the first year of life and were positively associated with iron levels only in infants with wild-type HFE gene, a situation that requires further investigation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 20%
Student > Master 3 20%
Student > Doctoral Student 2 13%
Researcher 2 13%
Professor 1 7%
Other 4 27%
Readers by discipline Count As %
Medicine and Dentistry 9 60%
Biochemistry, Genetics and Molecular Biology 3 20%
Nursing and Health Professions 2 13%
Agricultural and Biological Sciences 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2018.
All research outputs
#10,502,153
of 13,177,477 outputs
Outputs from Annals of Hematology
#733
of 1,118 outputs
Outputs of similar age
#201,145
of 268,149 outputs
Outputs of similar age from Annals of Hematology
#19
of 35 outputs
Altmetric has tracked 13,177,477 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,118 research outputs from this source. They receive a mean Attention Score of 2.4. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,149 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.