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Longitudinal Alzheimer’s Degeneration Reflects the Spatial Topography of Cholinergic Basal Forebrain Projections

Overview of attention for article published in Cell Reports, July 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

news
5 news outlets
blogs
2 blogs
twitter
31 tweeters

Citations

dimensions_citation
40 Dimensions

Readers on

mendeley
105 Mendeley
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Title
Longitudinal Alzheimer’s Degeneration Reflects the Spatial Topography of Cholinergic Basal Forebrain Projections
Published in
Cell Reports, July 2018
DOI 10.1016/j.celrep.2018.06.001
Pubmed ID
Authors

Taylor W. Schmitz, Marieke Mur, Meghmik Aghourian, Marc-Andre Bedard, R. Nathan Spreng

Abstract

The cholinergic neurons of the basal forebrain (BF) provide virtually all of the brain's cortical and amygdalar cholinergic input. They are particularly vulnerable to neuropathology in early Alzheimer's disease (AD) and may trigger the emergence of neuropathology in their cortico-amygdalar projection system through cholinergic denervation and trans-synaptic spreading of misfolded proteins. We examined whether longitudinal degeneration within the BF can explain longitudinal cortico-amygdalar degeneration in older human adults with abnormal cerebrospinal fluid biomarkers of AD neuropathology. We focused on two BF subregions, which are known to innervate cortico-amygdalar regions via two distinct macroscopic cholinergic projections. To further assess whether structural degeneration of these regions in AD reflects cholinergic denervation, we used the [18F] FEOBV radiotracer, which binds to cortico-amygdalar cholinergic terminals. We found that the two BF subregions explain spatially distinct patterns of cortico-amygdalar degeneration, which closely reflect their cholinergic projections, and overlap with [18F] FEOBV indices of cholinergic denervation.

Twitter Demographics

The data shown below were collected from the profiles of 31 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 105 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 25%
Researcher 18 17%
Student > Master 11 10%
Student > Doctoral Student 7 7%
Other 6 6%
Other 15 14%
Unknown 22 21%
Readers by discipline Count As %
Neuroscience 33 31%
Medicine and Dentistry 11 10%
Psychology 11 10%
Agricultural and Biological Sciences 7 7%
Biochemistry, Genetics and Molecular Biology 5 5%
Other 12 11%
Unknown 26 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 70. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2019.
All research outputs
#432,609
of 20,162,811 outputs
Outputs from Cell Reports
#1,008
of 9,732 outputs
Outputs of similar age
#11,521
of 294,026 outputs
Outputs of similar age from Cell Reports
#35
of 312 outputs
Altmetric has tracked 20,162,811 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,732 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.8. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,026 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 312 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.