Title |
Anaphylaxis in the 21st century: phenotypes, endotypes, and biomarkers
|
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Published in |
Journal of Asthma and Allergy, June 2018
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DOI | 10.2147/jaa.s159411 |
Pubmed ID | |
Authors |
Teodorikez Wilfox Jimenez-Rodriguez, Marlene Garcia-Neuer, Leila A Alenazy, Mariana Castells |
Abstract |
Anaphylaxis is the most serious of all allergic reactions and can be fatal. The diagnosis is frequently delayed, and misdiagnosis often occurs with asthma or urticaria. Biomarkers such as tryptase are not routinely checked, and appropriate treatment with epinephrine is not administered in a majority of cases, increasing the risk of poor outcomes. The objective of this review is to provide a better understanding of the pathophysiology of anaphylaxis with a description of phenotypes, endotypes, and biomarkers available in both the clinical and research settings. Expanding knowledge with regard to the presentation, causes, and triggers for anaphylaxis among health care providers will improve its diagnosis and management, increase patient safety, and decrease morbidity and mortality. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Solomon Islands | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 165 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 26 | 16% |
Researcher | 16 | 10% |
Other | 14 | 8% |
Student > Master | 11 | 7% |
Student > Doctoral Student | 10 | 6% |
Other | 32 | 19% |
Unknown | 56 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 56 | 34% |
Biochemistry, Genetics and Molecular Biology | 15 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 5% |
Immunology and Microbiology | 9 | 5% |
Agricultural and Biological Sciences | 5 | 3% |
Other | 12 | 7% |
Unknown | 59 | 36% |